1-BOC-4-甲磺酰基氧甲基哌啶合成路线 （共 14 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C;
参考文献
SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.
Patent: WO2011/31628 A1, 2011 ;
Location in patent: Page/Page column 72 ;
WO 2011/031628 A1
反应条件
methanesulfonyl chloride; triethylamine in tetrahydrofuran T=0°C; 1 h;
参考文献
WO2004/58781 A1, ;
Page 102-103 ;
WO 2004/058781 A1
反应条件
triethanolamine in dichloromethane
参考文献
US6878714 B2, ;
US 6878714 B2
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in CH2Cl2.; dichloromethane; water
反应条件
1: 100 percent / CH2Cl2 2: 100 percent / BH3*THF / tetrahydrofuran 3: Et3N / CH2Cl2 / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 24 p. 3161 - 3164
反应条件
1: 96 percent / CH2Cl2 / 0.5 h / Ambient temperature 2: 92.9 percent / triethylamine / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 38, # 7 p. 595 - 605
反应条件
1: 100 percent / BH3*THF / tetrahydrofuran 2: Et3N / CH2Cl2 / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 24 p. 3161 - 3164
反应条件
1: 100 percent / CH2Cl2 2: 100 percent / BH3*THF / tetrahydrofuran 3: Et3N / CH2Cl2 / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 24 p. 3161 - 3164
反应条件
lithium iodide in N,N-dimethyl-formamide
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP2017275 A1, 2009 ;
Location in patent: Page/Page column 53 ;
EP 2017275 A1
反应条件
1: NaN3 / dimethylformamide / Heating 2: 100 percent / H2 / 10 percent Pd/C / methanol View Scheme
参考文献
DONG-A PHARM.CO., LTD.; KIM, Soon-Hoe; IM, Weon-Bin; CHOI, Sung-Hak; CHOI, Sun-Ho; SOHN, Ju-Hee; SUNG, Hyun-Jung; KIM, Mi-Yeon; CHO, Kang-Hun; SOHN, Tae-Kyoung
Patent: WO2011/132901 A2, 2011 ;
WO 2011/132901 A2
