1-BOC-4-甲磺酰基氧甲基哌啶合成路线 （共 14 条）
反应条件
in ethanol; water T=80°C; 24 h;
参考文献
KOWA CO., LTD.; Morimoto, Toshiharu; Koshizawa, Tomoaki; Watanabe, Gen; Ohgiya, Tadaaki; Yamasaki, Nao; Inoue, Noriyuki
Patent: US2013/102621 A1, 2013 ;
Location in patent: Paragraph 0281; 0282 ;
反应条件
in ethanol 12 h; Heating / reflux;
参考文献
NOVO NORDISK A/S
Patent: WO2004/54973 A2, 2004 ;
Location in patent: Page 38 ;
WO 2004/054973 A2
反应条件
1: 1.) NaH / 1.) DMF, RT, 10 min., 2.) DMF, 60 deg C, 16 h
2: 95 percent / TFA / CH2Cl2 / 0.5 h / Ambient temperature
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参考文献
Waterhouse; Collier; O'Brien
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 3 p. 215 - 226
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C / Inert atmosphere
1.2: 16 h / 50 °C
2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
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参考文献
SCHERING CORPORATION; TING, Pauline, C.; LEE, Joe, F.; ASLANIAN, Robert, G.
Patent: WO2011/31628 A1, 2011 ;
WO 2011/031628 A1
