1-苯基-2-(4-吡啶)乙酮合成路线 （共 44 条）
反应条件
1: With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: 4-Methylpyridine in tetrahydrofuran; hexane
T=0°C; 2 h;
3: benzonitrile With hydrogen bromide
more than 3 stages;
参考文献
J. URIACH Y COMPANIA S.A.
Patent: WO2006/13095 A2, 2006 ;
Location in patent: Page/Page column 43 ;
WO 2006/013095 A2
反应条件
1: 4-Methylpyridine With lithium diisopropyl amide in tetrahydrofuran; cyclohexane
T=-78 - 0°C; 0.5 h;
2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; cyclohexane
T=-78 - 20°C;
参考文献
ALLERGAN, INC.
Patent: WO2009/91760 A1, 2009 ;
Location in patent: Page/Page column 37 ;
WO 2009/091760 A1
反应条件
sodium hydride in ethylene glycol dimethyl ether
65 h; Heating;
参考文献
Shilcrat; Hill; Bender; Griswold; Baures; Eggleston; Lantos; Pridgen
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 5 p. 1181 - 1187
反应条件
sodium carbonate in ethanol
2 h; Heating;
参考文献
Suzuki, Toshinobu; Mitsuhashi, Keiryo
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1487 - 1489
反应条件
sulfur; palladium on activated charcoal in various solvent(s)
4 h; Heating;
参考文献
Comins, Daniel L.; Brown, Jack D.
Tetrahedron Letters, 1984 , vol. 25, # 31 p. 3297 - 3300
反应条件
in dichloromethane; toluene
参考文献
Ippolito; Robert M.; Vigmond; Stephen
Patent: US4681944 A1, 1987 ;
反应条件
sulfuric acid; water
参考文献
Buehler et al.
Journal of Organic Chemistry, 1955 , vol. 20, p. 1350,1354
Full Text Show Details
Smith et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3997,3998
Full Text Show Details
Lukes; Ernest
Collection of Czechoslovak Chemical Communications, 1949 , vol. 14, p. 665,672
反应条件
oxygen in dichloromethane
168 h;
参考文献
Akiba, Kin-ya; Nishihara, Yoshihiro; Wada, Makoto
Tetrahedron Letters, 1983 , vol. 24, # 47 p. 5269 - 5272
反应条件
lithium diisopropyl amide
1.) THF, cyclohexane, -78 deg C, 1 h, 2.) THF, -78 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Shipkova, Petia A.; Qi, Ming; Nichols, Daniel A.; Burton, Richard D.; Watson, Clifford H.; Eyler, John R.; Tamm, Toomas; Karelson, Mati; Zerner, Michael C.
Journal of the American Chemical Society, 1996 , vol. 118, # 47 p. 11905 - 11911
反应条件
1: ethanolic KOH-solution
2: sulfuric acid; water
View Scheme
参考文献
Smith et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3997,3998
