3,5-二叔丁基-4-羟基苯甲醛合成路线 （共 132 条）
反应条件
sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane T=20°C; 18 h;
参考文献
Sexton, Karen E.; Lee, Helen T.; Massa, Mark; Padia, Janak; Patt, William C.; Liao, Peggy; Pontrello, Jason K.; Roth, Bruce D.; Spahr, Mark A.; Ramharack, Randy
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4827 - 4845
反应条件
potassium permanganate in sodium hydroxide; diethyl ether; water; Petroleum ether
参考文献
Fileco
Patent: US5487893 A1, 1996 ;
反应条件
potassium hydroxide; sodium hydroxide; water
参考文献
Mueller,E. et al.
Justus Liebigs Annalen der Chemie, 1961 , vol. 645, p. 36 - 52
反应条件
1: NH2OH*HCl, Py / ethanol; methanol / Heating 2: H2SO4 / Heating 3: aq. NaOH / Heating 4: SOCl2 / Heating View Scheme
参考文献
Mueller,E. et al.
Justus Liebigs Annalen der Chemie, 1961 , vol. 645, p. 36 - 52
反应条件
sodium cyanoborohydride; sodium hydrogencarbonate in tetrahydrofuran; methanol; trifluoroacetic acid
参考文献
Monash University
Patent: US6232314 B1, 2001 ;
反应条件
N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane T=20°C; 18 h; Heating / reflux;
参考文献
Centaur Pharmaceuticals, Inc.
Patent: US6342523 B1, 2002 ;
Location in patent: Page column 20-21 ;
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate; 1,2-dichloro-ethane; pentane
参考文献
Waterbury, L. David; Wood, Paul L.; Khan, M. Amin; Upasani, Ravindra B.
Patent: US2002/165274 A1, 2002 ;
反应条件
1.1: p-TsOH / benzene / 48 h / Heating 2.1: NaH / tetrahydrofuran; dimethylformamide / 0.17 h 2.2: 80 percent / tetrahydrofuran; dimethylformamide / 1 h 3.1: 100 percent / aq. HCl / acetone / 1 h View Scheme
参考文献
Amorati, Riccardo; Lucarini, Marco; Mugnaini, Veronica; Pedulli, Gian Franco; Roberti, Marinella; Pizzirani, Daniela
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7101 - 7107
反应条件
1: p-toluenesulfonic acid / toluene / Heating 2: H2 / RaNi / methanol; tetrahydrofuran / 20 °C View Scheme
参考文献
Sexton, Karen E.; Lee, Helen T.; Massa, Mark; Padia, Janak; Patt, William C.; Liao, Peggy; Pontrello, Jason K.; Roth, Bruce D.; Spahr, Mark A.; Ramharack, Randy
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4827 - 4845
反应条件
sulfuric acid in acetic acid 51 h; Ambient temperature;
参考文献
Varache-Beranger; Nuhrich; Amiell; Dufour; Devaux
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 5 p. 551 - 556
