3,4-二乙基-5-甲基-2-吡咯羧酸乙酯合成路线 （共 12 条）
反应条件
sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran Reduction;
参考文献
Boehme, Roswitha; Breitmaier, Eberhard
Synthesis, 1999 , # 12 p. 2096 - 2102
反应条件
hydrogenchloride; acetic anhydride in water
参考文献
Canadian Patents and Development Limited
Patent: US4070366 A1, 1978 ;
反应条件
1: 3-ethyl-2,4-hexanedione-O2,O4-difluoroboronate With sodium hydroxide in methanol; water Hydrolysis; pH=9.0; 0.5 h; Heating; 2: diethyl 2-hydroxyiminomalonate With zinc in acetic acid Condensation; Fischer-Knorr type condensation; 1 h; Heating;
参考文献
Huggins, Michael T.; Lightner, David A.
Tetrahedron, 2000 , vol. 56, # 13 p. 1797 - 1810
反应条件
acetic acid Heating;
参考文献
Paine, John B.; Dolphin, David
Journal of Organic Chemistry, 1985 , vol. 50, # 26 p. 5598 - 5604
反应条件
1.1: NaNO2 / acetic acid 1.2: 58 percent / Zn; NaOAc 2.1: 99 percent / NaBH4; BF3*OEt2 / tetrahydrofuran View Scheme
参考文献
Synthesis, , # 12 p. 2096 - 2102
反应条件
1.1: NaNO2 / acetic acid 1.2: 58 percent / Zn; NaOAc 2.1: 99 percent / NaBH4; BF3*OEt2 / tetrahydrofuran View Scheme
参考文献
Synthesis, , # 12 p. 2096 - 2102
反应条件
1: 1.) BF3, 2.) aq. KOH, propionic acid / 1.) from 30 deg C to 90 deg C, 120 min, 2.) acetone, ethanol 2: 63 percent / AcOH / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 26 p. 5598 - 5604
参考文献
Justus Liebigs Annalen der Chemie, , vol. 468, p. 61,74
反应条件
1: Br2, AcOH / 0.5 h 2: KOH / 4 h / Heating 3: O2, AcOH View Scheme
参考文献
Cheng, Lingjiang; Ma, Jinshi
Organic Preparations and Procedures International, 1995 , vol. 27, # 2 p. 224 - 228
反应条件
1: SO2Cl2; diethyl ether / Erhitzen des Reaktionsprodukts mit wss. Natriumacetat 2: aq. NaOH solution / 180 °C View Scheme
参考文献
Eisner et al.
Journal of the Chemical Society, 1957 , p. 733,736
