Pd(1,3-bis(diphenylphosphino)-propane)Cl2; lithium triethylborohydride in tetrahydrofuran T=0°C; 1 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4546405', constants.ctx, '0')">caesium carbonate</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '506523', constants.ctx, '0')">thiophenol</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=90&deg;C;&nbsp;4.25&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 88 percent / dimethylformamide / 22.5 h / Ambient temperature<br />2: 96 percent / t-BuOK / dimethylformamide / 14 h / 0 - 20 &deg;C<br />3: 70 percent / NaH, (Ph₃P)4Pd / tetrahydrofuran / 2 h / Ambient temperature<br />4: 88 percent / K₂CO₃ / methanol / 1.25 h<br />5: 87 percent / Cs₂CO₃, C₆H₅SH / dimethylformamide / 4.25 h / 90 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 96 percent / t-BuOK / dimethylformamide / 14 h / 0 - 20 &deg;C<br />2: 70 percent / NaH, (Ph₃P)4Pd / tetrahydrofuran / 2 h / Ambient temperature<br />3: 88 percent / K₂CO₃ / methanol / 1.25 h<br />4: 87 percent / Cs₂CO₃, C₆H₅SH / dimethylformamide / 4.25 h / 90 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1: 97 percent / PBr₃ / diethyl ether / 3 h / Ambient temperature<br />2: 88 percent / dimethylformamide / 22.5 h / Ambient temperature<br />3: 96 percent / t-BuOK / dimethylformamide / 14 h / 0 - 20 &deg;C<br />4: 70 percent / NaH, (Ph₃P)4Pd / tetrahydrofuran / 2 h / Ambient temperature<br />5: 88 percent / K₂CO₃ / methanol / 1.25 h<br />6: 87 percent / Cs₂CO₃, C₆H₅SH / dimethylformamide / 4.25 h / 90 &deg;C<br /> <br /> &nbsp;