7-氟-6-硝基-4-羟基喹唑啉合成路线 （共 13 条）
反应条件
sulfuric acid; nitric acid T=0 - 110°C; 3 h;
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
Location in patent: Page/Page column 25 ;
反应条件
sulfuric acid; nitric acid T=0 - 110°C; 3 h;
参考文献
HANMI PHARM. CO., LTD.
Patent: WO2007/55513 A1, 2007 ;
Location in patent: Page/Page column 20 ;
WO 2007/055513 A1
反应条件
sulfuric acid; nitric acid T=100°C; 1 h;
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Bridges, Alexander J.; Showalter, H.D. Hollis; Sun, Li; Nelson, James; McMichael, Amy; Kraker, Alan J.; Fry, David W.; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 918 - 928
反应条件
1: 2-methoxy-ethanol / 18 h / |Reflux 2: sulfuric acid; nitric acid / 2 h / 0 - 110 °C View Scheme
参考文献
ACS Medicinal Chemistry Letters, , vol. 4, # 10 p. 974 - 978
参考文献
Journal of Medicinal Chemistry, , vol. 52, # 21 p. 6880 - 6888
反应条件
hydrogenchloride; nickel monoaluminide in tetrahydrofuran; thionyl chloride; ethanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol
参考文献
Barth, Hubert; Steiner, Klaus; Schneider, Simon
Patent: US2003/50313 A1, 2003 ;
反应条件
1: methanol With sodium 0.166667 h; Inert atmosphere; 2: 7-fluoro-6-nitroquinazolin-4(3H)-one 3 h; Inert atmosphereReflux;
参考文献
HUTCHISON MEDIPHARMA LIMITED; ZHANG, Weihan; SU, Wei-Guo; YANG, Haibin; CUI, Yumin; REN, Yongxin; YAN, Xiaoqiang
Patent: WO2012/356 A1, 2012 ;
Location in patent: Page/Page column 12 ;
WO 2012/000356 A1
反应条件
1: in dimethyl sulfoxide 0.5 h; Cooling with ice; 2: With anhydrous potassium trimethylsilanolate in dimethyl sulfoxide
参考文献
HANMI HOLDINGS CO., LTD.; BAE, In Hwan; BYUN, Eun Young; JU, Hae Kyoung; SONG, Ji Young; JUNG, Seung Hyun; JUN, Mi Ae; KIM, Ho Seok; JUNG, Young Hee; SHIM, Mi Yon; AHN, Young Gil; KIM, Maeng Sup
Patent: WO2012/30160 A2, 2012 ;
Location in patent: Page/Page column 73 ;
反应条件
1: thionyl chloride 2: isopropyl alcohol View Scheme
参考文献
THE SCRIPPS RESEARCH INSTITUTE; CARROLL, Kate, S.
Patent: WO2014/89546 A1, 2014 ;
反应条件
thionyl chloride; trichlorophosphate; N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
Barth, Hubert; Bridges, Alexander James; Heemstra, Ronald J.; Horne, Nicole Marcia; Hughes, Robert Craig; Jacks, Thomas Elliott; McNamara, Dennis Joseph; Schneider, Simon; Steiner, Klaus; Toogood, Peter Laurence; Winters, Roy Thomas
Patent: US2004/158065 A1, 2004 ;
Location in patent: Page 18 ;
