7-氟-6-硝基-4-羟基喹唑啉合成路线 （共 13 条）
反应条件
1: 7-fluoro-6-nitroquinazolin-4(3H)-one With thionyl chloride; N,N-dimethyl-formamide
24 h; Heating / reflux;
2: 4-(3-hydroxypropyl)morpholine; para-fluoro-meta-chloroaniline in tetrahydrofuran; tert-butyl alcohol
T=10 - 20°C; 24 h;
3: With hydrogenchloride; potassium tert-butylate
more than 3 stages;
参考文献
Barth, Hubert; Bridges, Alexander James; Heemstra, Ronald J.; Horne, Nicole Marcia; Hughes, Robert Craig; Jacks, Thomas Elliott; McNamara, Dennis Joseph; Schneider, Simon; Steiner, Klaus; Toogood, Peter Laurence; Winters, Roy Thomas
Patent: US2004/158065 A1, 2004 ;
Location in patent: Page 20 ;
反应条件
hydrogenchloride in tetrahydrofuran; thionyl chloride; ethanol; N,N-dimethyl-formamide; toluene; tert-butyl alcohol
参考文献
Barth, Hubert; Steiner, Klaus; Schneider, Simon
Patent: US2003/50313 A1, 2003 ;
反应条件
1.1: sodium / 0.17 h / Inert atmosphere
1.2: 3 h / Inert atmosphere; Reflux
2.1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux
View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; ZHANG, Weihan; SU, Wei-Guo; YANG, Haibin; CUI, Yumin; REN, Yongxin; YAN, Xiaoqiang
Patent: WO2012/356 A1, 2012 ;
WO 2012/000356 A1
