4-(4-羧基苯基)哌嗪-1-羧酸叔丁酯合成路线 （共 9 条）
反应条件
sodium hydroxide in ethanol
参考文献
THERAVANCE, INC.
Patent: US2012/114600 A1, 2012 ;
反应条件
sodium hydroxide in ethanol; water T=60°C;
参考文献
WO2006/38039 A1, ;
Page/Page column 15 ;
反应条件
1: 40 percent / K2CO3 / dimethylsulfoxide / 10 h / 120 °C 2: aq. LiOH / tetrahydrofuran; methanol / 24 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 3 p. 1165 - 1181
反应条件
1: 40 percent / K2CO3 / dimethylsulfoxide / 10 h / 120 °C 2: aq. LiOH / tetrahydrofuran; methanol / 24 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 3 p. 1165 - 1181
反应条件
1: NaOH / H2O; dioxane / 1 h / 20 °C 2: 400 mg / NaOH / H2O; methanol; tetrahydrofuran / 8 h / 50 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 7 p. 2089 - 2108
反应条件
1: 20 °C 2: sodium hydroxide / water / 6 h / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661
反应条件
1: potassium carbonate / butan-1-ol / 177 h / |Reflux 2: 20 °C 3: sodium hydroxide / water / 6 h / 40 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661
反应条件
in hydrogenchloride; methanol
参考文献
THERAVANCE, INC.
Patent: US2012/114600 A1, 2012 ;
反应条件
borane-THF in tetrahydrofuran T=0°C; 5.25 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2007/27528 A2, 2007 ;
Location in patent: Page/Page column 47-48 ;
WO 2007/027528 A2
