4-(环丙基羰基)-alpha,alpha-二甲基苯乙酸合成路线 （共 12 条）
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=20°C; 1 h;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 89 ;
反应条件
nitric acid; sodium nitrite in acetic acid T=48 - 50°C; 2 h;
参考文献
Merrell Pharmaceuticals, Inc.
Patent: US6348597 B2, 2002 ;
Location in patent: Page column 90-91 ;
反应条件
sodium hydroxide in ethanol 21 h; Heating / reflux;
参考文献
Merrell Pharmaceuticals Inc.
Patent: US6242606 B1, 2001 ;
反应条件
hydrogenchloride 10 h; Heating / reflux;
参考文献
US6348597 B2, ;
Page column 81 ;
反应条件
1.1: sulfuric acid / 20 °C 2.1: 1-methyl-pyrrolidin-2-one / 160 - 165 °C 3.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / Inert atmosphere 3.2: 0 °C / Inert atmosphere 4.1: sodium hydroxide; methanol / 2 h / 20 °C 5.1: potassium permanganate; acetic acid / water; acetone / 0 - 20 °C View Scheme
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / Inert atmosphere 1.2: 0 °C / Inert atmosphere 2.1: sodium hydroxide; methanol / 2 h / 20 °C 3.1: potassium permanganate; acetic acid / water; acetone / 0 - 20 °C View Scheme
反应条件
1.1: 1-methyl-pyrrolidin-2-one / 160 - 165 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / Inert atmosphere 2.2: 0 °C / Inert atmosphere 3.1: sodium hydroxide; methanol / 2 h / 20 °C 4.1: potassium permanganate; acetic acid / water; acetone / 0 - 20 °C View Scheme
反应条件
1: methanol; sodium hydroxide / 4 h / 25 - 30 °C 2: water; acetic acid; potassium permanganate / acetone / 7 h / 25 - 45 °C View Scheme
参考文献
Research on Chemical Intermediates, , vol. 39, # 5 p. 2149 - 2155
反应条件
1: hydrogenchloride / 7 h / 40 - 45 °C 2: sodium tetrahydroborate / ethanol / 7 h / 25 - 30 °C 3: potassium hydrogencarbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / |Reflux 4: methanol; sodium hydroxide / 6 h / |Reflux View Scheme
参考文献
Ronggeng, Wang; Yougui, Zhao; Guanchao, Zhang
Research on Chemical Intermediates, 2013 , vol. 39, # 5 p. 2149 - 2155
