4-溴-2,6-吡啶二羧酸合成路线 （共 11 条）
反应条件
tetrabutylammomium bromide; phosphorus pentoxide in toluene T=100°C; 1 h;
参考文献
Kato, Yoshiaki; Okada, Shigemitsu; Tomimoto, Koji; Mase, Toshiaki
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4849 - 4851
反应条件
lithium hydroxide in tetrahydrofuran Hydrolysis; 2.75 h;
参考文献
Pryor, Kent E.; Shipps Jr., Gerald W.; Skyler, David A.; Rebek Jr., Julius
Tetrahedron, 1998 , vol. 54, # 16 p. 4107 - 4124
反应条件
bromine; phosphorus tribromide in ethanol
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 44, p. S236 - S238
反应条件
1: 6.56 g / CHCl3 / ice cooling 2: 91 percent / aq. LiOH / tetrahydrofuran / 2.75 h View Scheme
参考文献
Tetrahedron, , vol. 54, # 16 p. 4107 - 4124
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane Chlorination; 20 h; Heating;
参考文献
Pryor, Kent E.; Shipps Jr., Gerald W.; Skyler, David A.; Rebek Jr., Julius
Tetrahedron, 1998 , vol. 54, # 16 p. 4107 - 4124
反应条件
1: 90 percent / NH2NH2 / ethanol View Scheme
参考文献
Bleicher, Konrad H.; Nettekoven, Matthias; Peters, Jens-Uwe; Wyler, Rene
Chimia, 2004 , vol. 58, # 9 p. 588 - 600
反应条件
1: oxalyl chloride; DMF / benzene / 6 h / Heating 2: sodium azide; tetra-n-butylammonium bromide / CH2Cl2; H2O / 0.5 h / -5 - 0 °C View Scheme
参考文献
Bleicher, Konrad H.; Nettekoven, Matthias; Peters, Jens-Uwe; Wyler, Rene
Chimia, 2004 , vol. 58, # 9 p. 588 - 600
反应条件
hydrogenchloride in methanol T=20°C; 15 h;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP2017279 A1, 2009 ;
Location in patent: Page/Page column 43 ;
EP 2017279 A1
参考文献
Arico, Fabio; Chang, Theresa; Cantrill, Stuart J.; Khan, Saeed I.; Stoddart, J. Fraser
Chemistry - A European Journal, 2005 , vol. 11, # 16 p. 4655 - 4666
反应条件
sodium tetrahydroborate
参考文献
Schmidt, Boris; Ehlert, Dennis K.
Tetrahedron Letters, 1998 , vol. 39, # 23 p. 3999 - 4002
