8-溴-4-羟基-5-(1-甲基乙氧基)-2-萘羧酸乙酯合成路线 （共 7 条）
反应条件
in ethanol 4 h; Ambient temperature;
参考文献
Bringmann, Gerhard; Goetz, Roland; Harmsen, Sven; Holenz, Joerg; Walter, Rainer
Liebigs Annales, 1996 , # 12 p. 2045 - 2058
反应条件
1: 62 percent / Br2, NaOAc / CH2Cl2 2: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 6 h, 2.) r.t., overnight 3: 97 percent / 90percent aq. TFA / 3 h 4: 89 percent / 6 h / Heating 5: 95 percent / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Bringmann, Gerhard; Goetz, Roland; Keller, Paul A.; Walter, Rainer; Henschel, Petra; et al.
Heterocycles, 1994 , vol. 39, # 2 p. 503 - 508
反应条件
1: 88 percent / K2CO3 / dimethylformamide / 17 h / 90 °C 2: 62 percent / Br2, NaOAc / CH2Cl2 3: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 6 h, 2.) r.t., overnight 4: 97 percent / 90percent aq. TFA / 3 h 5: 89 percent / 6 h / Heating 6: 95 percent / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Bringmann, Gerhard; Goetz, Roland; Keller, Paul A.; Walter, Rainer; Henschel, Petra; et al.
Heterocycles, 1994 , vol. 39, # 2 p. 503 - 508
反应条件
1: 61 percent / NaH / tetrahydrofuran / 1.) 0 deg C, 6 h, 2.) r.t., overnight 2: 97 percent / 90percent aq. TFA / 3 h 3: 89 percent / 6 h / Heating 4: 95 percent / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Bringmann, Gerhard; Goetz, Roland; Keller, Paul A.; Walter, Rainer; Henschel, Petra; et al.
Heterocycles, 1994 , vol. 39, # 2 p. 503 - 508
反应条件
1: 89 percent / 6 h / Heating 2: 95 percent / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Liebigs Annales, , # 12 p. 2045 - 2058
反应条件
1: 97 percent / 90percent aq. TFA / 3 h 2: 89 percent / 6 h / Heating 3: 95 percent / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Liebigs Annales, , # 12 p. 2045 - 2058
反应条件
potassium carbonate in acetone 15 h; Heating;
参考文献
Bringmann, Gerhard; Goetz, Roland; Harmsen, Sven; Holenz, Joerg; Walter, Rainer
Liebigs Annales, 1996 , # 12 p. 2045 - 2058
