1-Boc-3-氨甲基哌啶合成路线 （共 7 条）
反应条件
hydrazine hydrate in ethanol T=20°C; 24 h;
参考文献
Banyu Pharmaceutical Co., Ltd.
Patent: EP2261210 A1, 2010 ;
Location in patent: Page/Page column 46 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 24 h;
参考文献
Martini, Elisabetta; Ghelardini, Carla; Dei, Silvia; Guandalini, Luca; Manetti, Dina; Melchiorre, Michele; Norcini, Monica; Scapecchi, Serena; Teodori, Elisabetta; Romanelli, Maria Novella
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1431 - 1443
反应条件
sodium tetrahydroborate; nickel dichloride in tetrahydrofuran; methanol T=0°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 17 p. 2325 - 2330
反应条件
1: methanol 2: Lawesson's reagent / tetrahydrofuran / Heating 3: NiCl2*6H2O; NaBH4 / tetrahydrofuran; methanol / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 17 p. 2325 - 2330
反应条件
1: methanol 2: Lawesson's reagent / tetrahydrofuran / Heating 3: NiCl2*6H2O; NaBH4 / tetrahydrofuran; methanol / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 17 p. 2325 - 2330
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
WO2004/2483 A1, ;
Page/Page column 23; 41 ;
WO 2004/002483 A1
