1,3-二氢-1-(-4-哌啶基)(2H)吲哚-2-酮合成路线 （共 11 条）
反应条件
formic acid; palladium on activated charcoal in methanol T=60°C; 4 h;
参考文献
SRI INTERNATIONAL
Patent: WO2005/60947 A2, 2005 ;
Location in patent: Page/Page column 34 ;
WO 2005/060947 A2
反应条件
in diethyl ether; dichloromethane; trifluoroacetic acid
参考文献
Butler, Christopher R.; Cai, Hui; Edwards, James P.; Grice, Cheryl A.; Gu, Yin; Gustin, Darin J.; Karlsson, Lars; Khatuya, Haripada; Meduna, Steven P.; Pio, Barbara A.; Sehon, Clark A.; Sun, Siquan; Tays, Kevin L.; Thurmond, Robin L.; Wei, Jianmei
Patent: US2005/101587 A9, 2005 ;
反应条件
palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tert-butyl alcohol T=85°C; Suzuki cross-coupling; 3 h;
参考文献
van den Hoogenband, Adri; Lange, Jos H.M.; Iwema-Bakker, Wouter I.; den Hartog, Jack A.J.; van Schaik, Jord; Feenstra, Rolf W.; Terpstra, Jan Willem
Tetrahedron Letters, 2006 , vol. 47, # 26 p. 4361 - 4364
反应条件
hydrogen; palladium on activated charcoal P=2585.74 Torr;
参考文献
Tetrahedron Letters, , vol. 42, # 39 p. 6943 - 6945
反应条件
1: K2CO3 / acetonitrile / 20 °C 2: PhB(OH)2; X-Phos; K2CO3 / Pd(OAc)2 / 2-methyl-propan-2-ol / 2 h / 85 °C 3: ammonium formate / Pd/C / methanol / 0.05 h / 140 °C / microwave irradiation View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 12 p. 3421 - 3425
反应条件
1: K2CO3 / acetonitrile / 20 °C 2: PhB(OH)2; X-Phos; K2CO3 / Pd(OAc)2 / 2-methyl-propan-2-ol / 2 h / 85 °C 3: ammonium formate / Pd/C / methanol / 0.05 h / 140 °C / microwave irradiation View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 12 p. 3421 - 3425
反应条件
1: PhB(OH)2; X-Phos; K2CO3 / Pd(OAc)2 / 2-methyl-propan-2-ol / 2 h / 85 °C 2: ammonium formate / Pd/C / methanol / 0.05 h / 140 °C / microwave irradiation View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 12 p. 3421 - 3425
反应条件
1: NaBH(OAc)3 2: 4-toluenesulfonic acid / toluene / 1 h / Heating 3: H2 / Pd/C / 2585.74 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 39 p. 6943 - 6945
反应条件
1: NaBH(OAc)3 2: 4-toluenesulfonic acid / toluene / 1 h / Heating 3: H2 / Pd/C / 2585.74 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 39 p. 6943 - 6945
反应条件
1: 100 percent / H2 / Pd/C / ethyl acetate / 2585.74 Torr 2: NaBH(OAc)3 3: 4-toluenesulfonic acid / toluene / 1 h / Heating 4: H2 / Pd/C / 2585.74 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 39 p. 6943 - 6945
