1,3-二氢噻吩并[3,2-d]嘧啶-2,4-二酮合成路线 （共 20 条）
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 60, # 8 p. 1037 - 1045
反应条件
acetic acid in water T=25°C; 5 h;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 20 p. 6614 - 6618
反应条件
1: With cyanic acid sodium salt in water; acetic acid T=20°C; 5 h; 2: With sodium hydroxide in water T=0°C;
参考文献
WO2011/49332 A2, ;
Page/Page column 16 ;
WO 2011/049332 A2
反应条件
1: With sodium hydroxide in methanol; water 1 h; Heating / reflux; 2: With sulfuric acid in methanol; water pH=< 1;
参考文献
WO2005/49033 A1, ;
Page/Page column 108 ;
WO 2005/049033 A1
反应条件
hydrogenchloride; urea in pyridine; water
反应条件
acetic acid; sodium nitrite in water T=60°C; 2 h;
参考文献
US2009/75970 A1, ;
Page/Page column 13 ;
US 20090075970 A1
反应条件
acetic acid 5 h; Ambient temperature;
参考文献
Nucleosides and Nucleotides, , vol. 13, # 4 p. 925 - 937
参考文献
US2010/233164 A1, ;
US 20100233164 A1
反应条件
1: 8 percent / conc. HCl, sodium nitrite / H2O / 0.08 h 2: 0.5 h / 200 °C View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 548 - 575
反应条件
T=200°C; 0.5 h; Yield given;
参考文献
Journal of Chemical Research, Miniprint, , # 2 p. 548 - 575
