乙酸-[2-(4-辛酰基苯基)]乙酯合成路线 （共 10 条）
反应条件
1: octanoic acid chloride With AlCl3, aluminium chloride in 1,2-dichloro-ethane T=20°C; 1 h; 2: beta-phenethyl acetate in 1,2-dichloro-ethane T=20°C; 12 h;
参考文献
Baek, Dong Jae; MacRitchie, Neil; Pyne, Nigel J.; Pyne, Susan; Bittman, Robert
Chemical Communications, 2013 , vol. 49, # 21 p. 2136 - 2138
反应条件
aluminium trichloride in nitrogen
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.; Taito Co., Ltd.
Patent: US5604229 A1, 1997 ;
反应条件
1.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 3.1: Et3N / CH2Cl2 / 1 h / 20 °C 4.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 5.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 5.2: 61 percent / ethanol / 3 h / 65 °C 6.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 7.1: 8.25 g / pyridine / 16 h / 20 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2: 3.40 g / NaOMe; MeOH / 2 h / Heating View Scheme
参考文献
Baek, Dong Jae; MacRitchie, Neil; Pyne, Nigel J.; Pyne, Susan; Bittman, Robert
Chemical Communications, 2013 , vol. 49, # 21 p. 2136 - 2138
反应条件
1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2: 3.40 g / NaOMe; MeOH / 2 h / Heating 3: Et3N / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Baek, Dong Jae; MacRitchie, Neil; Pyne, Nigel J.; Pyne, Susan; Bittman, Robert
Chemical Communications, 2013 , vol. 49, # 21 p. 2136 - 2138
反应条件
1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2: 3.40 g / NaOMe; MeOH / 2 h / Heating 3: Et3N / CH2Cl2 / 1 h / 20 °C 4: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 3.1: Et3N / CH2Cl2 / 1 h / 20 °C 4.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 5.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 5.2: 61 percent / ethanol / 3 h / 65 °C 6.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
triethylsilane; trifluoroacetic acid T=20°C; 3 h;
参考文献
Baek, Dong Jae; MacRitchie, Neil; Pyne, Nigel J.; Pyne, Susan; Bittman, Robert
Chemical Communications, 2013 , vol. 49, # 21 p. 2136 - 2138
反应条件
1.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 3.1: Et3N / CH2Cl2 / 1 h / 20 °C 4.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 5.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 5.2: 61 percent / ethanol / 3 h / 65 °C 6.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 7.1: 8.25 g / pyridine / 16 h / 20 °C 8.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 3.1: Et3N / CH2Cl2 / 1 h / 20 °C 4.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 5.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 5.2: 61 percent / ethanol / 3 h / 65 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
