4-(2-碘代乙基)辛基苯合成路线 （共 16 条）
反应条件
triethylsilane in trifluoroacetic acid
反应条件
iodine; triphenylphosphine in ether (200 ml)-acetonitrile
反应条件
lithium iodide in tetrahydrofuran T=20°C; 4 h;
参考文献
Seidel, Guenter; Laurich, Daniel; Fuerstner, Alois
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3950 - 3952
反应条件
1: Et3N / CH2Cl2 / 1 h 2: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1: 93 percent / NaOMe / methanol / 8 h / 20 °C 2: Et3N / CH2Cl2 / 1 h 3: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3: 3.40 g / NaOMe; MeOH / 2 h / Heating 4: Et3N / CH2Cl2 / 1 h / 20 °C 5: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3: 3.40 g / NaOMe; MeOH / 2 h / Heating 4: Et3N / CH2Cl2 / 1 h / 20 °C 5: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2: 3.40 g / NaOMe; MeOH / 2 h / Heating 3: Et3N / CH2Cl2 / 1 h / 20 °C 4: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1: 98 percent / NaHSO4 on silica / hexane / 26 h / Heating 2: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 3: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h 4: Et3N / CH2Cl2 / 1 h 5: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
