二乙基2-乙酰胺基-2-(4-辛基苯乙基)丙二酸酯合成路线 （共 21 条）
反应条件
triethylsilane; titanium tetrachloride in dichloromethane T=20°C;
参考文献
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; Haufe, Guenter; Levkau, Bodo; Schaefers, Michael; Schilson, Stefani Silke; Keul, Petra
Patent: US2014/170067 A1, 2014 ;
Location in patent: Paragraph 0490; 0491; 0492; 0493; 0494; 0495; 0496 ;
反应条件
hydrogen; 5-palladium/activated carbon in ethanol T=55°C; P=3000.3 - 7500.75 Torr; 63 h;
参考文献
WO2009/115534 A1, ;
Page/Page column 25-26 ;
反应条件
1: diethyl 2-acetylaminomalonate With sodium hydride in N,N-dimethyl-formamide 30 h; 2: 2-(4-octylphenyl)-1-iodoethane in N,N-dimethyl-formamide T=50 - 60°C; 1 h;
参考文献
Seidel, Guenter; Laurich, Daniel; Fuerstner, Alois
Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3950 - 3952
反应条件
NaH in N-methyl-acetamide; water
反应条件
5 Pd/C; hydrogen in ethanol
参考文献
Matsumoto, Norimasa; Hirose, Ryoji; Sasaki, Shigeo; Fujita, Tetsuro
Chemical and Pharmaceutical Bulletin, 2008 , vol. 56, # 4 p. 595 - 597
反应条件
1.1: Et3N / CH2Cl2 / 1 h 2.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 3.1: NaH / dimethylformamide / 30 h 3.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1.1: 93 percent / NaOMe / methanol / 8 h / 20 °C 2.1: Et3N / CH2Cl2 / 1 h 3.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 4.1: NaH / dimethylformamide / 30 h 4.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 2.1: NaH / dimethylformamide / 30 h 2.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1.1: AlCl3 2.1: NaOEt / ethanol / 1 h / 60 °C 2.2: 90 percent / ethanol / 1 h / 60 °C 3.1: 83 percent / Et3SiH; TiCl4 / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 20 p. 4470 - 4474
反应条件
1.1: NaOEt / ethanol / 1 h / 60 °C 1.2: 90 percent / ethanol / 1 h / 60 °C 2.1: 83 percent / Et3SiH; TiCl4 / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 20 p. 4470 - 4474
