二乙基2-乙酰胺基-2-(4-辛基苯乙基)丙二酸酯合成路线 （共 21 条）
反应条件
1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 4.1: Et3N / CH2Cl2 / 1 h / 20 °C 5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 6.2: 61 percent / ethanol / 3 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 4.1: Et3N / CH2Cl2 / 1 h / 20 °C 5.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 6.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 6.2: 61 percent / ethanol / 3 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2.1: 3.40 g / NaOMe; MeOH / 2 h / Heating 3.1: Et3N / CH2Cl2 / 1 h / 20 °C 4.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 5.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 5.2: 61 percent / ethanol / 3 h / 65 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: 98 percent / NaHSO4 on silica / hexane / 26 h / Heating 2.1: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 3.1: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h 4.1: Et3N / CH2Cl2 / 1 h 5.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 6.1: NaH / dimethylformamide / 30 h 6.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1.1: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2.1: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h 3.1: Et3N / CH2Cl2 / 1 h 4.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 5.1: NaH / dimethylformamide / 30 h 5.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1.1: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h 2.1: Et3N / CH2Cl2 / 1 h 3.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 4.1: NaH / dimethylformamide / 30 h 4.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 11 p. 3950 - 3952
反应条件
1.1: NaOEt / ethanol / 1 h / 60 °C 1.2: 90 percent / ethanol / 1 h / 60 °C 2.1: 83 percent / Et3SiH; TiCl4 / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 20 p. 4470 - 4474
反应条件
1: triethylamine / dichloromethane / 0 - 20 °C 2: caesium carbonate / acetonitrile / 4 h / |Reflux 3: triethylsilane; titanium tetrachloride / dichloromethane / 20 °C View Scheme
反应条件
1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 2: 8.25 g / pyridine / 16 h / 20 °C View Scheme
参考文献
Abel, Stephan; Fujita, Tetsuro; Hirose, Ryoji; Jordine, Guido; Mishina, Tadashi
Patent: US2002/72635 A1, 2002 ;
反应条件
sodium tetrahydroborate; water; calcium chloride in ethanol T=0°C;
参考文献
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER; HAUFE, Guenter; LEVKAU, Bodo; SCHAEFERS, Michael; SCHILSON, Stefani Silke; KEUL, Petra
Patent: WO2013/26765 A1, 2013 ;
Location in patent: Page/Page column 65-66 ;
