N-[1,1-双[(乙酰基氧基)甲基]-3-苯基丙基]乙酰胺合成路线 （共 5 条）
反应条件
acetic anhydride in tetrahydrofuran; pyridine
参考文献
YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.
Patent: EP1002792 A1, 2000 ;
反应条件
1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 2: pyridine / 16 h / 20 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3.1: pyridine / 16 h / 20 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 1.2: ethanol / 3 h / 65 °C 2.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 3.1: pyridine / 16 h / 20 °C View Scheme
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
反应条件
pyridine T=20°C; Acetylation; 16 h;
参考文献
Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro
Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961
