5-硝基-2-苯基苯并[b]呋喃合成路线 （共 19 条）
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; methanol
参考文献
US2005/197331 A1, ;
Page/Page column 21-22 ;
反应条件
1: 2-Iodo-4-nitrophenol With copper(l) iodide; triphenylphosphine; L-prolinol; palladium on activated charcoal in water
T=25°C; Sonogashira coupling; 1 h;
2: phenylacetylene in water
T=80°C; 3 h;
参考文献
Pal, Manojit; Subramanian, Venkataraman; Yeleswarapu, Koteswar Rao
Tetrahedron Letters, 2003 , vol. 44, # 45 p. 8221 - 8225
反应条件
triethylamine in toluene
T=20°C; 5 h; Heating / reflux;
参考文献
ROTTAPHARM S.P.A.
Patent: EP1571142 A1, 2005 ;
Location in patent: Page/Page column 30 ;
反应条件
triethylamine in toluene
T=20°C; 5 h; Heating / reflux;
参考文献
ROTTAPHARM SPA
Patent: US2005/197331 A1, 2005 ;
Location in patent: Page/Page column 21-22 ;
反应条件
4-(N,N-dimethlyamino)pyridine; trifluoroacetyl triflate in dichloromethane
T=20°C; 22 h;
参考文献
Takeda, Norihiko; Miyata, Okiko; Naito, Takeaki
European Journal of Organic Chemistry, 2007 , # 9 p. 1491 - 1509
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; silica gel in dimethyl sulfoxide
T=20 - 110°C; 0.05 h; Inert atmosphereMicrowave irradiation;
参考文献
Wu, Liansheng; Shi, Xiaokang; Xu, Xiaoyun; Liang, Fen; Huang, Guosheng
Journal of Chemical Sciences, 2011 , vol. 123, # 5 p. 697 - 702
反应条件
1: C8H5Br2NO3 With tetrabutyl ammonium fluoride in N,N-dimethyl-formamide
T=20°C; 4 h; Sealed tubeInert atmosphere;
2: benzenesulphinic acid sodium salt With copper diacetate; triethylamine; palladium dichloride in N,N-dimethyl-formamide
T=110°C; 12 h; Sealed tubeInert atmosphere;
参考文献
Chen, Wei; Li, Pinhua; Miao, Tao; Meng, Ling-Guo; Wang, Lei
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 3 p. 420 - 424
反应条件
tetrabutyl ammonium fluoride; palladium diacetate; triphenylphosphine in 1-methyl-pyrrolidin-2-one
T=80°C; tandem elimination-addition-Hiyama coupling; 12 h;
参考文献
Liu, Jie; Chen, Wei; Ji, Yong; Wang, Lei
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 8 p. 1585 - 1592
反应条件
1.1: NaNO2; aq. H2SO4 / dimethylsulfoxide / 0 °C
1.2: KI / dimethylsulfoxide / 20 °C
2.1: 66 percent / CuI / Pd(PPh3)2Cl2 / acetonitrile; toluene / 0.33 h / 20 °C
View Scheme
参考文献
Dai, Wei-Min; Lai, Kwong Wah
Tetrahedron Letters, 2002 , vol. 43, # 51 p. 9377 - 9380
反应条件
copper(l) iodide; Na2[PdCl4]; N,N,N',N,-tetramethylethylenediamine; cataCXium PIntB in tetrahydrofuran
T=80°C; 1.5 h; Inert atmosphere;
参考文献
Bochicchio, Antonella; Chiummiento, Lucia; Funicello, Maria; Lopardo, Maria Teresa; Lupattelli, Paolo
Tetrahedron Letters, 2010 , vol. 51, # 21 p. 2824 - 2827
