4-二氟甲氧基-3-甲氧基苯甲醛合成路线 （共 5 条）
反应条件
caesium carbonate in DMF (N,N-dimethyl-formamide); water T=100°C; 3.5 h;
参考文献
ALMIRALL PRODESFARMA SA
Patent: WO2005/58883 A1, 2005 ;
Location in patent: Page/Page column 131 ;
WO 2005/058883 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=65 - 70°C; 16 h;
参考文献
Williams, Spencer J.; Zammit, Steven C.; Cox, Alison J.; Shackleford, David M.; Morizzi, Julia; Zhang, Yuan; Powell, Andrew K.; Gilbert, Richard E.; Krum, Henry; Kelly, Darren J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6868 - 6873
反应条件
in 1,4-dioxane; 1-chloro-1,1-difluoro-methane; ethyl acetate; toluene
参考文献
US5712298 A1, ;
US 5712298 A
参考文献
Xiao, You-An; Wang, Zhi-Qiang; Wang, Xue-Min; Hui, Yi; Ling, Yong; Wang, Xin-Yang; He, Li-Qin
Chinese Chemical Letters, 2013 , vol. 24, # 8 p. 727 - 730
反应条件
potassium carbonate in 1-methyl-pyrrolidin-2-one
参考文献
Xiao, You-An; Wang, Zhi-Qiang; Wang, Xue-Min; Hui, Yi; Ling, Yong; Wang, Xin-Yang; He, Li-Qin
Chinese Chemical Letters, 2013 , vol. 24, # 8 p. 727 - 730
