2-(1-甲基-1H-吡唑-3-基)吡啶合成路线 （共 6 条）
反应条件
1: 2-(1H-pyrazol-3-yl)pyridine With sodium hydride in tetrahydrofuran 1 h; 2: methyl iodide in tetrahydrofuran T=20°C; 18 h;
参考文献
CALCIMEDICA, INC.; ROGERS, Evan; CAO, Jianguo; WANG, Zhijun; GREY, Jonathan; WHITTEN, Jeffrey, P.
Patent: WO2014/59333 A1, 2014 ;
Location in patent: Paragraph 00485 ;
反应条件
potassium fluoride; copper(l) iodide; palladium diacetate; di-(1-adamantyl)-n-butylphosphine in N,N-dimethyl-formamide T=90°C; Hiyama coupling; 12 h; Inert atmosphere;
参考文献
Blakemore, David C.; Marples, Louise A.
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4192 - 4195
反应条件
in ethanol T=60°C; 0.5 h;
参考文献
Uber, Jorge Salinas; Vogels, Yorick; Van Den Helder, Dave; Mutikainen, Ilpo; Turpeinen, Urho; Fu, Wen Tian; Roubeau, Olivier; Gamez, Patrick; Reedijk, Jan
European Journal of Inorganic Chemistry, 2007 , # 26 p. 4197 - 4206
反应条件
1: 1.5 h / 110 °C 2: ethanol / 85 °C 3: sodium hydride / tetrahydrofuran / 65 °C View Scheme
参考文献
Yu, Xian-Yong; Deng, Lin; Zheng, Baishu; Zeng, Bi-Rong; Yi, Pinggui; Xu, Xin
Dalton Transactions, 2014 , vol. 43, # 4 p. 1524 - 1533
反应条件
1: ethanol / 85 °C 2: sodium hydride / tetrahydrofuran / 65 °C View Scheme
参考文献
Yu, Xian-Yong; Deng, Lin; Zheng, Baishu; Zeng, Bi-Rong; Yi, Pinggui; Xu, Xin
Dalton Transactions, 2014 , vol. 43, # 4 p. 1524 - 1533
反应条件
in V methoxymethyl ester 6 h; Inert atmosphereReflux;
参考文献
Comes Franchini, Mauro; Bonini, Bianca Flavia; Camaggi, Carlo Maurizio; Gentili, Denis; Pession, Annalisa; Rani, Monica; Strocchi, Elena
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2024 - 2033
