11-beta,17-alpha,21-三羟基-6-alpha-甲基孕甾-4-烯-3,20-二酮合成路线 （共 8 条）
反应条件
hydrogen; Wilkinson's catalyst in ethanol; ethyl acetate T=20°C; P=760.051 Torr; 168 h;
参考文献
AstraZeneca RandD
Patent: US2010/256105 A1, 2010 ;
Location in patent: Page/Page column 12 ;
3386-05-82-[(6S,8S,9S,10R,11S,13S,14S)-11-羟基-6,10,13-三甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-亚基]乙基乙酸酯
→
反应条件
1: diacetoxy-phenyl-iodan; OsO4; pyridine / Reagens 4: tert-Butylalkohol 2: Hydrolysis View Scheme
参考文献
Spero et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 6213
参考文献
Spero et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 6213
参考文献
Cooley et al.
Journal of the Chemical Society, 1957 , p. 4112,4114
反应条件
1: aqueous H2SO4; methanol 2: aqueous methanol.NaOH View Scheme
参考文献
Cooley et al.
Journal of the Chemical Society, 1957 , p. 4112,4114
反应条件
1: diethyl ether; tetrahydrofuran 2: aqueous H2SO4; methanol 3: aqueous methanol.NaOH View Scheme
参考文献
Cooley et al.
Journal of the Chemical Society, 1957 , p. 4112,4114
反应条件
pyridine in ethyl acetate T=20 - 55°C;
参考文献
AstraZeneca RandD
Patent: US2010/256105 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
ueber mehrere Stufen;
参考文献
Spero et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1515
