(4S,5R)-(-)-4-甲基-5-苯基-2-噁唑烷酮合成路线 （共 28 条）
反应条件
carbon in tetrahydrofuran T=20°C; 16 h;
参考文献
Alouane, Nacira; Boutier, Audrey; Baron, Cyriella; Vrancken, Emmanuel; Mangeney, Pierre
Synthesis, 2006 , # 5 p. 885 - 889
反应条件
TEA in dichloromethane T=-78 - 0°C;
参考文献
Hein, Jason E.; Zimmerman, Jake; Sibi, Mukund P.; Hultin, Philip G.
Organic Letters, 2005 , vol. 7, # 13 p. 2755 - 2758
反应条件
zinc(II) chloride; lithium diisopropyl amide in tetrahydrofuran; hexane T=-70°C; Evans aldol addition; 1.5 h;
参考文献
Klar, Ulrich; Buchmann, Bernd; Schwede, Wolfgang; Skuballa, Werner; Hoffmann, Jens; Lichtner, Rosemarie B.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 47 p. 7942 - 7948
反应条件
1: With methanesulfonyl chloride; triethylamine in tetrahydrofuran T=0 - 45°C; 3.08333 h; 2: With lithium hydroxide; water T=60 - 90°C;
参考文献
US2008/58551 A1, ;
Page/Page column 4 ;
反应条件
trimethylaluminum; O,N-dimethyl-hydroxylamine hydrochloride in tetrahydrofuran; dichloromethane; toluene T=-10 - 0°C;
参考文献
Journal of Organic Chemistry, , vol. 61, # 16 p. 5326 - 5351
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; Substitution; 0.5 h;
参考文献
Journal of Organic Chemistry, , vol. 63, # 17 p. 5895 - 5902
反应条件
potassium hydroxide in methanol; water T=35°C;
参考文献
Journal of the American Chemical Society, , vol. 103, # 20 p. 6157 - 6163
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With trimethylaluminum in tetrahydrofuran; toluene T=0 - 20°C; 2: (4S,5R)-3-((E)-(2R,3S)-3-Hydroxy-2,4-dimethyl-hept-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one in tetrahydrofuran; toluene T=50°C; 1.5 h;
参考文献
Tetrahedron, , vol. 60, # 38 p. 8509 - 8527
反应条件
1: (4S,5R)-4-methyl-5-phenyl-1,3-oxazolidine-2-thione With sodium hydride in tetrahydrofuran T=0°C; 0.75 h; 2: (2E)-3-phenylprop-2-enoyl chloride in tetrahydrofuran T=0°C; 1 h;
参考文献
Ortiz, Aurelio; Quintero, Leticia; Mendoza, Guadalupe; Bernes, Sylvain
Tetrahedron Letters, 2003 , vol. 44, # 27 p. 5053 - 5055
反应条件
sodium tetrahydroborate in tetrahydrofuran; water T=20°C; 6 h;
参考文献
Kinoshita, Hironori; Osamura, Takashi; Mizuno, Kazumi; Kinoshita, Sayaka; Iwamura, Tatsunori; Watanabe, Shin-Ichi; Kataoka, Tadashi; Muraoka, Osamu; Tanabe, Genzoh
Chemistry - A European Journal, 2006 , vol. 12, # 14 p. 3896 - 3904
