(2R,3S)-3-(叔丁氧羰基氨基)-1-氯-2-羟基-4-苯基丁烷合成路线 （共 12 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran; water T=0°C; 0.75 h;
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
Rhodococcus erythropolis SC 13845 in phosphate buffer pH=7.0; 49 h; Microbiological reaction;
参考文献
Patel, Ramesh N.; Chu, Linda; Mueller, Richard
Tetrahedron Asymmetry, 2003 , vol. 14, # 20 p. 3105 - 3109
反应条件
anhydrous potassium hydrogen sulfate in diethyl ether; ethyl acetate
参考文献
Ajinomoto Co., Inc.
Patent: US2002/72621 A1, 2002 ;
反应条件
sodium hydroxide in methanol; dichloromethane; water T=25°C; pH=7; 2 h; Product distribution / selectivity;
参考文献
Ajinomoto Co., Inc.
Patent: EP1777213 A1, 2007 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogenchloride in diethyl ether
反应条件
sodium hydroxide in methanol; water; toluene T=25°C; pH=7; 3 h; Product distribution / selectivity;
参考文献
EP1777213 A1, ;
Page/Page column 21 ;
反应条件
potassium phosphate buffer; Streptomyces nodosus SC 13149 T=28°C; microbial reduction; pH=6.8; 48 h;
参考文献
Patel, Ramesh N.
JAOCS, Journal of the American Oil Chemists' Society, 1999 , vol. 76, # 11 p. 1275 - 1281
反应条件
1: 4-methylmorpholine / tetrahydrofuran / 0.33 h / -25 - -20 °C 2: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 3: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C 4: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1758 - 1768
反应条件
1: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C 2: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1758 - 1768
反应条件
1: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 2: 92 percent / HCl / dioxane; diethyl ether / 1 h / 0 °C 3: 50 percent / NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1758 - 1768
