N-甲氧羰基-L-叔亮氨酸合成路线 （共 9 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=60°C; pH=8 - 9; 18 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; VAMSI KRISHNA, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; MADHANMOHAN REDDY, Musku
Patent: WO2011/80562 A1, 2011 ;
Location in patent: Page/Page column 34 ;
反应条件
1: hydrogenchloride / toluene; water / 3 h / 60 °C 2: sodium hydroxide / water / 2 h / 25 °C / pH 10 - 13 View Scheme
反应条件
methylamine in methanol; toluene+20; water; toluene
参考文献
DSM N.V.
Patent: US2001/41812 A1, 2001 ;
反应条件
in methanol; n-heptane; water; toluene
参考文献
DSM N.V.
Patent: US2001/41812 A1, 2001 ;
反应条件
4-methyl-morpholine; diisopropyl-carbodiimide in dichloromethane; isopropyl alcohol T=-10 - 20°C; Inert atmosphere; Product distribution / selectivity;
参考文献
ESTEVE QUIMICA, S.A.; BARTRA SANMARTI, Marti; BERENGUER MAIMO, Ramon; ORTIZ GIL, Jordi; ISERN SANCHEZ, Olga
Patent: WO2010/146119 A1, 2010 ;
Location in patent: Page/Page column 9-11 ;
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Zhang, Huiping; Bonacorsi Jr., Samuel J.; Chen, Bang-Chi; Leith, Leslie W.; Rinehart, J. Kent; Balasubramanian, Balu; Barrish, Joel C.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 14 p. 1041 - 1047
反应条件
1: (S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=25 - 30°C; 2: (2S,3S)-3-amino-4-phenyl-1-(1-(4-(pyridin-2-yl)benzyl)hydrazinyl)butan-2-ol hydrochloride With N-ethyl-N,N-diisopropylamine in dichloromethane; water 3 h; Product distribution / selectivity;
参考文献
LUPIN LIMITED; MAHAKAL, Kumodini, Kashinath; SINGH, Gurvinder, Pal; RAY, Purna, Chandra
Patent: WO2011/107843 A2, 2011 ;
Location in patent: Page/Page column 16; 17 ;
反应条件
1: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C 2: 25 percent / propan-2-ol / 24 h / Heating 3: HCl / tetrahydrofuran; H2O / 5 h / 50 °C 4: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 View Scheme
参考文献
Fan, Xing; Song, Yan-Li; Long, Ya-Qiu
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 69 - 75
反应条件
1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -25 - 20 °C 2.1: sodium iodide / acetonitrile / 0.25 h / 20 °C 2.2: 0.25 h / 20 °C 3.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 0 °C View Scheme
参考文献
Fan, Xing; Song, Yan-Li; Long, Ya-Qiu
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 69 - 75
