2-羟基-3-苯基丙基氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
in tetrahydrofuran T=20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/121786 A1, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/121786 A1
反应条件
1: 1-amino-3-phenylpropan-2-ol hydrochloride With triethylamine in tetrahydrofuran T=20°C; 0.166667 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 2 h;
参考文献
Sumino, Yukihito; Okamoto, Kazuya; Masui, Moriyasu; Akiyama, Toshiyuki
Patent: US2012/22251 A1, 2012 ;
Location in patent: Page/Page column 36-37 ;
反应条件
pyridine; N,N'-dimethyl-N,N'-propyleneurea; anhydrous 4,4'-bipyridyl; NiI2*3.9H2O; triethyl amine hydrochloride; sodium iodide; zinc T=20°C; 12 h;
参考文献
Zhao, Yang; Weix, Daniel J.
Journal of the American Chemical Society, 2014 , vol. 136, # 1 p. 48 - 51
反应条件
1: LiAlH4 / diethyl ether 2: 89 percent / N-methylmorpholine / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Moree, Wilna J.; Marel, Gijs A. van der; Liskamp, Rob J.
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5157 - 5169
反应条件
1: ZnI2 2: LiAlH4 / diethyl ether 3: 89 percent / N-methylmorpholine / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Moree, Wilna J.; Marel, Gijs A. van der; Liskamp, Rob J.
Journal of Organic Chemistry, 1995 , vol. 60, # 16 p. 5157 - 5169
反应条件
1: ammonium hydroxide / water / 12 h / 25 °C / Seled tube 2: tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/121786 A1, 2008 ;
WO 2008/121786 A1
