3,5-二氯-1,2-苯并异噁唑合成路线 （共 4 条）
反应条件
pyridine in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; trichlorophosphate
参考文献
Sankyo Company, Limited
Patent: US5965591 A1, 1999 ;
反应条件
1: carbonyldiimidazole / tetrahydrofuran / Heating 2: POCl3, Et3N / Heating View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
1: NH2OH*HCl, aq. NaOH 2: carbonyldiimidazole / tetrahydrofuran / Heating 3: POCl3, Et3N / Heating View Scheme
参考文献
Yevich, Joseph P.; New, James S.; Smith, David W.; Lobeck, Walter G.; Catt, John D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 359 - 369
反应条件
sodium hydroxide in 2-ethoxy-ethanol 18 h; Heating;
参考文献
Boeshagen,H.
Chemische Berichte, 1967 , vol. 100, # 10 p. 3326 - 3330
