西罗莫司脂化物合成路线

162635-03-2(1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-二羟基-19,30-二甲氧基-15,17,21,23,29,35-六甲基-2,3,10,14,20-五氧代-11,36-二氧杂-4-氮杂三环[30.3.1.04,9]三十六碳-16,24,26,28-四烯-12-基]丙基}-2-甲氧基环己基2,2,5-三甲基-1,3-二恶烷-5-羧酸酯

162635-04-3西罗莫司脂化物

参考文献

Gu, Jianxin; Ruppen, Mark E.; Cai, Ping
Organic Letters, 2005 , vol. 7, # 18 p. 3945 - 3948

1296664-73-7

162635-04-3西罗莫司脂化物

参考文献

CADILA HEALTHCARE LIMITED; DAVE, Mayank, Ghanshyambhai; PANDEY, Bipin
Patent: WO2011/51960 A2, 2011 ;
Location in patent: Page/Page column 30 ;

1246021-94-2

162635-04-3西罗莫司脂化物

参考文献

Lee, Kwang-Chung; Lee, Ting-Huei; Tung, Yen-Shih; Kao, Chia-Chen; Lee, Tzu-Ai
Patent: US2010/249415 A1, 2010 ;
Location in patent: Page/Page column 13 ;

1316755-19-7

162635-04-3西罗莫司脂化物

参考文献

FRESENIUS KABI ONCOLOGY LTD; GUPTA, Nitin; HANDA, Vishal; PAL, Abir, Kumar; SINGH, Hemat, Kumar; LAHIRI, Saswata; DUBEY, Sushil, Kumar
Patent: WO2011/92564 A2, 2011 ;
Location in patent: Page/Page column 22 ;

1296664-84-0

162635-04-3西罗莫司脂化物

参考文献

CADILA HEALTHCARE LIMITED; DAVE, Mayank, Ghanshyambhai; PANDEY, Bipin
Patent: WO2011/51960 A2, 2011 ;
Location in patent: Page/Page column 37 ;

107-41-52-甲基-2,4-戊二醇

162635-04-3西罗莫司脂化物

参考文献

Tianjin Weijie Technology Co., Ltd.; SONG, Honghai; TANG, Long; CHEN, Wei; LI, Zheng; LI, Jinzhou; SUN, Zhicun; FENG, Jiajin
Patent: EP2662377 A1, 2013 ;
Location in patent: Paragraph 0031 ;

1316755-20-0

162635-04-3西罗莫司脂化物

参考文献

US2011/184167 A1, ;

Page/Page column 14 ;

1296664-68-0

162635-04-3西罗莫司脂化物

参考文献

WO2011/51960 A2, ;

Page/Page column 24-25 ;

1296664-76-0

162635-04-3西罗莫司脂化物

参考文献

WO2011/51960 A2, ;

Page/Page column 33 ;