1-苄基-4-羟甲基-4-氰基哌啶合成路线 （共 4 条）
反应条件
1: 1-(phenylmethyl)-4-piperidinecarbonitrile With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: formaldehyd in tetrahydrofuran T=-60°C; 2 h; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
WO2007/30061 A1, ;
Page/Page column 91 ;
WO 2007/030061 A1
反应条件
sodium hydroxide in dichloromethane T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/30061 A1, 2007 ;
Location in patent: Page/Page column 91 ;
WO 2007/030061 A1
反应条件
hydrogen; 5 Pd(OH)2/C in methanol
T=20°C; P=2250.23 Torr;
参考文献
ASTRAZENECA AB
Patent: WO2007/30061 A1, 2007 ;
Location in patent: Page/Page column 92-93 ;
WO 2007/030061 A1
反应条件
1: 1-(phenylmethyl)-4-piperidinecarbonitrile With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h;
2: formaldehyd in tetrahydrofuran
T=-60°C; 2 h;
3: With ammonium chloride in tetrahydrofuran; water
参考文献
ASTRAZENECA AB
Patent: WO2007/30061 A1, 2007 ;
Location in patent: Page/Page column 91 ;
WO 2007/030061 A1
