4-氯噻吩并[3,2-d]嘧啶合成路线 （共 23 条）
反应条件
oxalyl dichloride in dichloromethane; N,N-dimethyl-formamide T=0°C; 5 h; Heating / reflux;
参考文献
Yang, Beom-Seok; Kim, Yong-Zu; Park, Tae-Kyo; Woo, Sung-Ho; Lee, Hyang-Sook; Kim, Sun-Young; Cho, Jong-Un; Lee, Hong-Bum
Patent: US2013/72482 A1, 2013 ;
Location in patent: Paragraph 0211; 0216; 0217 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
sulfuryl dichloride in dichloromethane; acetonitrile T=0°C; 0.5 h;
参考文献
Ham, Young Jin; Lee, Duck-Hyung; Choi, Hwan Geun; Hah, Jung-Mi; Sim, Taebo
Tetrahedron Letters, 2010 , vol. 51, # 35 p. 4609 - 4611
反应条件
in anhydrous dichloroethane; dichloromethane
参考文献
Pfizer Inc.
Patent: US6492383 B1, 2002 ;
反应条件
1: CH3COONH4 / Heating 2: HCOONH4; HCONH2 / 140 °C 3: oxalyl chloride / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 21 - 24
反应条件
1: HCOONH4; HCONH2 / 140 °C 2: oxalyl chloride / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 21 - 24
反应条件
hydrogen; palladium on activated charcoal
参考文献
Bulletin de la Societe Chimique de France, , p. 3630 - 3636
反应条件
1: POCl3, Py 2: H2 / Pd-C View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 3630 - 3636
反应条件
1: 90 percent / 4 h / Heating 2: POCl3 / 2 h / Heating View Scheme
参考文献
Heterocyclic Communications, , vol. 13, # 1 p. 33 - 34
