4-氯噻吩并[3,2-d]嘧啶合成路线 （共 23 条）
反应条件
1: (catalytic reduction) 2: Br2 View Scheme
参考文献
Robba,M. et al.
Tetrahedron, 1971 , vol. 27, p. 487 - 499
反应条件
ammonia in methanol T=100°C;
参考文献
Robba,M. et al.
Tetrahedron, 1971 , vol. 27, p. 487 - 499
反应条件
1: n-butyllithium; iodine / 2 h / -78 - 20 °C
2: tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; cesium fluoride / 1,4-dioxane; water / 3 h / Reflux
View Scheme
参考文献
Ni, Yike; Gopalsamy, Ariamala; Cole, Derek; Hu, Yonghan; Denny, Rajiah; Ipek, Manus; Liu, Julie; Lee, Julie; Hall, J. Perry; Luong, Michael; Telliez, Jean-Baptiste; Lin, Lih-Ling
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5952 - 5956
