(Z)-3, 4, 5, 4’-四甲氧基-3’-氨基二苯乙烯合成路线 （共 14 条）
反应条件
sodium tetrahydroborate; nickel dichloride in methanol
T=20°C; 0.5 h;
参考文献
Pettit, George R.; Rhodes, Monte R.; Herald, Delbert L.; Hamel, Ernest; Schmidt, Jean M.; Pettit, Robin K.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 4087 - 4099
反应条件
ammonia; ammonium formate; platinum on carbon in water; acetonitrile
T=30°C; 19.5 - 23 h;
参考文献
Ajinomoto Co., Inc.
Patent: EP1405843 A1, 2004 ;
Location in patent: Page 6; 8 ;
反应条件
ammonia; ammonium formate; palladium 10 on activated carbon in water; acetonitrile
T=30°C; 24 - 28 h;
参考文献
Ajinomoto Co., Inc.
Patent: EP1405843 A1, 2004 ;
Location in patent: Page 7 ;
反应条件
hydrogen; platinum on carbon in methanol
T=20°C; 16 h;
参考文献
Ajinomoto Co., Inc.
Patent: EP1405843 A1, 2004 ;
Location in patent: Page 8-9 ;
反应条件
hydrogen; platinum(IV) oxide in acetonitrile
T=20 - 55°C; 27 h;
参考文献
Ajinomoto Co., Inc.
Patent: EP1405843 A1, 2004 ;
Location in patent: Page 8-9 ;
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -23 °C
1.2: 66 percent / tetrahydrofuran; hexane / 21 h / -23 - 20 °C
2.1: 63 percent / NiCl2*6H2O; NaBH4 / methanol / 0.5 h / 20 °C
View Scheme
参考文献
Pettit, George R.; Rhodes, Monte R.; Herald, Delbert L.; Hamel, Ernest; Schmidt, Jean M.; Pettit, Robin K.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 4087 - 4099
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -23 °C
1.2: 66 percent / tetrahydrofuran; hexane / 21 h / -23 - 20 °C
2.1: 63 percent / NiCl2*6H2O; NaBH4 / methanol / 0.5 h / 20 °C
View Scheme
参考文献
Pettit, George R.; Rhodes, Monte R.; Herald, Delbert L.; Hamel, Ernest; Schmidt, Jean M.; Pettit, Robin K.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 12 p. 4087 - 4099
反应条件
1: N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl4 / Heating
2: CH2Cl2 / Heating
3: sodium hydride / CH2Cl2 / 0 - 20 °C
4: sodium dithionite / acetone; H2O / 50 °C
View Scheme
参考文献
Monk, Keith A.; Siles, Rogelio; Hadimani, Mallinath B.; Mugabe, Benon E.; Ackley, J. Freeland; Studerus, Scott W.; Edvardsen, Klaus; Trawick, Mary Lynn; Garner, Charles M.; Rhodes, Monte R.; Pettit, George R.; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 3231 - 3244
反应条件
1: CH2Cl2 / Heating
2: sodium hydride / CH2Cl2 / 0 - 20 °C
3: sodium dithionite / acetone; H2O / 50 °C
View Scheme
参考文献
Monk, Keith A.; Siles, Rogelio; Hadimani, Mallinath B.; Mugabe, Benon E.; Ackley, J. Freeland; Studerus, Scott W.; Edvardsen, Klaus; Trawick, Mary Lynn; Garner, Charles M.; Rhodes, Monte R.; Pettit, George R.; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 9 p. 3231 - 3244
反应条件
1: copper(l) iodide; ammonium hydroxide / 48 h / 80 °C / |Sealed tube
2: copper(l) iodide; 1,10-phenanthroline / 180 - 190 °C / |Microwave irradiation; |Inert atmosphere; |Green chemistry
View Scheme
参考文献
Zou, Yong; Huang, Qi; Huang, Tong-Kun; Ni, Qing-Chun; Zhang, En-Sheng; Xu, Tian-Long; Yuan, Mu; Li, Jun
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 40 p. 6967 - 6974
