2-(4-氯苯基)-1-(4-吡啶)乙酮合成路线 （共 4 条）
反应条件
1: With ethanol; sodium hydride T=20°C; 2.75 h; Heating / reflux; 2: With hydrogenchloride; water 3: With water; hydrogen bromide; potassium carbonate more than 3 stages;
参考文献
Mikkilineni, Amarendra B.; Murugesan, Natesan; Yu, Guixue
Patent: US2006/287342 A1, 2006 ;
Location in patent: Page/Page column 10 ;
US 20060287342 A1
反应条件
hydrogen bromide 1.) ether, reflux, 2 h; 2.) reflux, 12 h, 2-propanol, ether, aqueous sodium bicarbonate; Multistep reaction;
参考文献
Bunting, John W.; Stefanides, Dimitrios
Journal of the American Chemical Society, 1988 , vol. 110, # 12 p. 4008 - 4017
反应条件
hydrogenchloride in tetrahydrofuran; water; isopropyl alcohol 2 h; Ambient temperature; Yield given;
参考文献
Journet, Michel; Cai, Dongwei; Larsen, Robert D.; Reider, Paul J.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1717 - 1720
反应条件
1: 83 percent / propan-2-ol; various solvent(s) / 4 h / Ambient temperature 2: anh. Cs2CO3 / tetrahydrofuran; propan-2-ol / 16 h / Ambient temperature 3: 3N HCl / H2O; tetrahydrofuran; propan-2-ol / 2 h / Ambient temperature View Scheme
参考文献
Journet, Michel; Cai, Dongwei; Larsen, Robert D.; Reider, Paul J.
Tetrahedron Letters, 1998 , vol. 39, # 13 p. 1717 - 1720
