4-溴-2,6-二氟苄基溴合成路线 （共 4 条）
反应条件
hydrogen bromide in acetic acid T=20°C; 1.5 h;
参考文献
PFIZER INC.
Patent: WO2004/74270 A2, 2004 ;
Location in patent: Page 170 ;
反应条件
lithium bromide in N,N-dimethyl-formamide T=90°C; 0.75 h;
参考文献
WO2007/21710 A1, ;
Page/Page column 59 ;
WO 2007/021710 A1
反应条件
in dimethyl sulfoxide T=23°C; 3 h;
参考文献
GLAXOSMITHKLINE LLC; GHERGUROVICH, Jonathan, Michael; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; RIDGERS, Lance, Howard; YU, Hongyi
Patent: WO2013/28447 A1, 2013 ;
Location in patent: Page/Page column 111 ;
反应条件
1: dimethyl sulfoxide / 3 h / 23 °C 2: sulfuric acid; acetic acid / 1 h / 100 °C 3: sodium hydroxide; water / ethanol / 80 °C View Scheme
