1-(2,4-二氯苯基)-5-对氯苯基-4-甲基-吡唑-3-甲酸合成路线 （共 25 条）
反应条件
1: in ethanol 2.5 h; Heating / reflux; 2: With sodium hydroxide in ethanol T=20°C; 2 h; Heating / reflux;
参考文献
US2007/287734 A1, ;
Page/Page column 28 ;
US 20070287734 A1
反应条件
sodium hydroxide in 1,4-dioxane T=70°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 5 p. 1151 - 1154
反应条件
potassium hydroxide in ethanol T=80°C; 3 h; Reflux;
参考文献
Synthetic Communications, , vol. 44, # 1 p. 32 - 41
反应条件
1: With sodium t-butanolate; bis(dibenzylideneacetone)-palladium(0); N-[2'-(dicyclohexylphosphino)-1,1'-biphenyl-2-yl]-N,N-dimethylamine in toluene T=120°C; 15 h; 2: With hydrogenchloride; water pH=1.5; Product distribution / selectivity;
参考文献
WO2008/101860 A1, ;
Page/Page column 7 ;
反应条件
1: With sodium hydroxide in ethanol 3 h; Reflux; 2: With hydrogenchloride in ethanol; water pH=1;
参考文献
US2010/160383 A1, ;
Page/Page column 4 ;
反应条件
1: With pyridine; copper diacetate in dichloromethane T=20°C; 48 h; 4 Å molecular sievesUnder air; 2: With sodium hydroxide; water T=70°C; 4 h; 3: With hydrogenchloride in water pH=1.5; Product distribution / selectivity;
参考文献
WO2008/101860 A1, ;
Page/Page column 7 ;
反应条件
1.1: 65 percent / LDA; potassium t-butoxide / diethyl ether; tetrahydrofuran; heptane / 2.5 h / 20 °C 2.1: HCl / H2O; CH2Cl2 3.1: ethanol / 2.5 h / Heating 3.2: 89 percent / NaOH / ethanol / 2 h / Heating View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 45, # 1 p. 59 - 70
参考文献
US2007/213302 A1, ;
Page/Page column 11; 12; 27 ;
US 20070213302 A1
反应条件
magnesium chloride in tetrahydrofuran T=80°C; 2 - 4 h; Product distribution / selectivity;
参考文献
WO2008/64615 A2, ;
Page/Page column 15-16 ;
反应条件
magnesium chloride in acetonitrile T=80°C; 2 - 4 h; Product distribution / selectivity;
参考文献
WO2008/64615 A2, ;
Page/Page column 16 ;
