1-(2,4-二氯苯基)-5-对氯苯基-4-甲基-吡唑-3-甲酸合成路线 （共 25 条）
反应条件
1: 1-(4-chlorophenyl)-1-propanone With lithium hexamethyldisilazane in 2-methyl cyclohexane T=25°C; Inert atmosphere; 2: oxalic acid diethyl ester in 2-methyl cyclohexane Inert atmosphere; 3: 2,4-dichloro-phenyl-hydrazine hydrochloride With sulfuric acid in ethanol T=79°C; 14 h;
参考文献
Organic Process Research and Development, , vol. 11, # 5 p. 910 - 912
反应条件
in acetonitrile T=80°C; 2 - 4 h; Product distribution / selectivity;
参考文献
WO2008/64615 A2, ;
Page/Page column 16 ;
反应条件
1: triethylamine / ethanol / 20 h / 20 °C 2: acetic acid / 24 h / Reflux 3: water; potassium hydroxide / ethanol / 3 h / Reflux View Scheme
参考文献
Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 2 p. 222 - 230
反应条件
in acetonitrile T=80°C; 2 - 4 h; Product distribution / selectivity;
参考文献
WO2008/64615 A2, ;
Page/Page column 16 ;
反应条件
1: triethylamine / ethanol / 20 h / 20 °C 2: acetic acid / 24 h / Reflux 3: water; potassium hydroxide / ethanol / 3 h / Reflux View Scheme
参考文献
Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 26, # 2 p. 222 - 230
反应条件
1.1: lithium hexamethyldisilazane / 2-methyl cyclohexane / 3 h / 20 °C 1.2: 16 h 1.3: |Cooling with ice; |Reflux 2.1: potassium hydroxide / ethanol / 12 h / 50 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 10 - 21
反应条件
1: 42 percent / NaH / tetrahydrofuran / 1.5 h / Heating 2: sodium / ethanol / 2.5 h / 0 °C 3: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis View Scheme
参考文献
Medicinal Chemistry Research, , vol. 5, # 1 p. 54 - 62
反应条件
1: 24 percent HCl; NaNO2 / H2O / 0 - 5 °C 2: sodium / ethanol / 2.5 h / 0 °C 3: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis View Scheme
参考文献
Medicinal Chemistry Research, , vol. 5, # 1 p. 54 - 62
反应条件
1: sodium / ethanol / 2.5 h / 0 °C 2: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis View Scheme
参考文献
Medicinal Chemistry Research, , vol. 5, # 1 p. 54 - 62
反应条件
1: sodium / ethanol / 2.5 h / 0 °C 2: 45 percent / NaOH / ethanol / 1.5 h / Alkaline hydrolysis View Scheme
参考文献
Medicinal Chemistry Research, , vol. 5, # 1 p. 54 - 62
