4-(1H-1,2,3-噻唑-1-基)苯胺合成路线 （共 4 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol
T=20°C;
参考文献
Kitazaki, Tomoyuki; Ichikawa, Takashi; Tasaka, Akihiro; Hosono, Hiroshi; Matsushita, Yoshihiro; Hayashi, Ryogo; Okonogi, Kenji; Itoh, Katsumi
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1935 - 1946
反应条件
1: With sodium hydride in N,N-dimethyl-formamide
T=20°C;
2: With platinum(IV) oxide; hydrogen in tetrahydrofuran
T=20°C;
参考文献
MERCK CANADA INC.; BOYD, Michael John; CHIASSON, Jean-François; CRANE, Sheldon; GIROUX, André
Patent: WO2013/59928 A1, 2013 ;
Location in patent: Page/Page column 33-34 ;
反应条件
1: Cs2CO3 / 60 - 100 °C
2: H2 / Pd/C / methanol / 20 °C / 760 Torr
View Scheme
参考文献
Jia, Zhaozhong J.; Wu, Yanhong; Huang, Wenrong; Zhang, Penglie; Clizbe, Lane A.; Goldman, Erick A.; Sinha, Uma; Arfsten, Ann E.; Edwards, Susan T.; Alphonso, Merlyn; Hutchaleelaha, Athiwat; Scarborough, Robert M.; Zhu, Bing-Yan
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 5 p. 1221 - 1227
反应条件
1: 67 percent / methanol / 1 h / -3 °C
2: 94 percent / H2 / 10 percent Pd/C / ethanol; tetrahydrofuran / 6 h / 50 °C
View Scheme
参考文献
Ichikawa, Takashi; Kitazaki, Tomoyuki; Matsushita, Yoshihiro; Hosono, Hiroshi; Yamada, Masami; Mizuno, Masahiro; Itoh, Katsumi
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1947 - 1953
