反应条件
1: 1.) Mg, BrCH2CH2Br, I2 / 1.) Et2O, reflux, 1 h, 2.) 16 h
2: conc. HCl / ethanol / 2 h / Heating
3: 1.) CH3ONa, 2.) 1.2M NaOH, Bu4NHSO4 / 1.) DMF, 35 deg C, 1 h, 2.) CH2Cl2, H2O, 10 min
4: 89 percent / NaOH / H2O; methanol / 0.08 h / Heating
View Scheme
参考文献
Jarman, Michael; McCague, Raymond
Journal of Chemical Research, Miniprint, 1985 , # 4 p. 1342 - 1388
