4-(1,2,4-三唑-1-基)苯甲酸合成路线 （共 4 条）
反应条件
1: With potassium carbonate in 1-methyl-pyrrolidin-2-one T=190°C; 0.5 h; Microwave irradiation; 2: With hydrogenchloride in 1-methyl-pyrrolidin-2-one; water
参考文献
WO2012/123449 A1, ;
Page/Page column 85 ;
WO 2012/123449 A1
反应条件
1: With silver nitrate; sodium hydroxide in water T=60°C; 24 h; 2: With hydrogenchloride in water pH=Ca. 2;
参考文献
Wang, Yu-Ling; Fu, Jiang-Hong; Wei, Jia-Jia; Xu, Xiang; Li, Xin-Fa; Liu, Qing-Yan
Crystal Growth and Design, 2012 , vol. 12, # 9 p. 4663 - 4668
反应条件
1: With sodium hydroxide in tetrahydrofuran; ethanol T=20°C; 2 h; 2: With hydrogenchloride in water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6359134 B1, 2002 ;
Location in patent: Referential example 17 ;
US 6359134 B1
反应条件
1.1: Aliquatreg; 336; potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 90 °C 1.2: 24 h / 90 °C 2.1: silver nitrate; sodium hydroxide / water / 24 h / 60 °C 2.2: pH Ca. 2 View Scheme
参考文献
Crystal Growth and Design, , vol. 12, # 9 p. 4663 - 4668
