（2S，3S，5S）-5-（叔丁氧基甲酰氨基）-2-（N-5-噻唑基-甲氧羰基）氨基-1，6-二苯基-3-羟基己烷合成路线 （共 6 条）
反应条件
1: in acetonitrile T=20°C; 0.333333 h; 2: With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 48 h;
参考文献
GILEAD SCIENCES, INC.; CULLEN, Aaron, J.; YU, Richard, Hung Chiu
Patent: WO2013/116715 A1, 2013 ;
Location in patent: Page/Page column 70 ;
反应条件
in tetrahydrofuran; N,N-dimethyl-formamide T=20°C;
参考文献
Hamada, Yoshio; Ohtake, Jun; Sohma, Youhei; Kimura, Tooru; Hayashi, Yoshio; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 4155 - 4167
反应条件
sodium hydrogencarbonate in water; ethyl acetate T=20 - 60°C; 9 h;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/90270 A1, 2006 ;
Location in patent: Page/Page column 11 ;
反应条件
EPHP; dibenzoyl peroxide in 1,4-dioxane T=105°C; 4 h;
参考文献
GILEAD SCIENCES, INC.; CULLEN, Aaron, J.; YU, Richard, Hung Chiu
Patent: WO2013/116715 A1, 2013 ;
Location in patent: Page/Page column 71-72 ;
反应条件
in ethyl acetate; N,N-dimethyl-formamide
参考文献
Abbott Laboratories
Patent: US5484801 A1, 1996 ;
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 3 h;
参考文献
ABBOTT LABORATORIES
Patent: WO2008/27932 A2, 2008 ;
Location in patent: Page/Page column 96 ;
WO 2008/027932 A2
