5-甲氧基嘧啶-2(1H)-酮合成路线 （共 6 条）
反应条件
hydrogenchloride in methanol 16 h; Reflux;
参考文献
Array Biopharma, Inc.
Patent: US2010/63066 A1, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
sodium hydroxide; water T=50°C; Hydrolysis;
参考文献
Jacobsen, Stig Andre; Rodbotten, Synne; Benneche, Tore
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 22 p. 3265 - 3268
反应条件
1: 87 percent / POCl3; N,N-dimethylaniline / 2 h / Heating 2: 98 percent / Zn; NH4Cl; H2O / benzene / 8 h / Heating 3: 87 percent / MCPBA / CH2Cl2 / 20 °C 4: 74 percent / NaOH; H2O / 50 °C View Scheme
参考文献
Jacobsen, Stig Andre; Rodbotten, Synne; Benneche, Tore
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 22 p. 3265 - 3268
反应条件
1: 87 percent / MCPBA / CH2Cl2 / 20 °C 2: 74 percent / NaOH; H2O / 50 °C View Scheme
参考文献
Jacobsen, Stig Andre; Rodbotten, Synne; Benneche, Tore
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 22 p. 3265 - 3268
反应条件
1: 98 percent / Zn; NH4Cl; H2O / benzene / 8 h / Heating 2: 87 percent / MCPBA / CH2Cl2 / 20 °C 3: 74 percent / NaOH; H2O / 50 °C View Scheme
参考文献
Jacobsen, Stig Andre; Rodbotten, Synne; Benneche, Tore
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 22 p. 3265 - 3268
反应条件
hydrogenchloride in water 20 h; Heatingother temperatures, other reaction times; KineticsRate constantThermodynamic data;
参考文献
Klimes; Zahradnicek
Die Pharmazie, 1987 , vol. 42, # 8 p. 511 - 513
