(S)-3-(4-苄氧基苯基)-2-羟基丙酸合成路线 （共 11 条）
反应条件
1: With potassium hydrogensulfate in 1,4-dioxane; water T=0 - 5°C; 1 h; 2: With sodium nitrite in 1,4-dioxane; water T=30°C; 4 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2005/19152 A2, 2005 ;
Location in patent: Page/Page column 12; 13 ;
反应条件
lithium hydroxide in tetrahydrofuran T=20°C; 20 h;
参考文献
Valls, Nativitat; Vallribera, Merce; Lopez-Canet, Meritxell; Bonjoch, Josep
Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4945 - 4950
反应条件
1: (+)-DIP-Cl; Et3N / tetrahydrofuran 2: K2CO3 / ethanol / 24 h / Heating 3: 60.81 g / NaOH / H2O / 2 h / 20 °C View Scheme
参考文献
Aikins, James A.; Haurez, Michael; Rizzo, John R.; Van Hoeck, Jean-Pierre; Brione, Willy; Kestemont, Jean-Paul; Stevens, Christophe; Lemair, Xavier; Stephenson, Gregory A.; Marlot, Eric; Forst, Mindy; Houpis, Ioannis N.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4695 - 4705
反应条件
1: K2CO3 / ethanol / 24 h / Heating 2: 60.81 g / NaOH / H2O / 2 h / 20 °C View Scheme
参考文献
Aikins, James A.; Haurez, Michael; Rizzo, John R.; Van Hoeck, Jean-Pierre; Brione, Willy; Kestemont, Jean-Paul; Stevens, Christophe; Lemair, Xavier; Stephenson, Gregory A.; Marlot, Eric; Forst, Mindy; Houpis, Ioannis N.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4695 - 4705
反应条件
1.1: (+)-DIP-Cl; Et3N / tetrahydrofuran 1.2: K2CO3 / ethanol 2.1: 60.81 g / NaOH / H2O / 2 h / 20 °C View Scheme
参考文献
Aikins, James A.; Haurez, Michael; Rizzo, John R.; Van Hoeck, Jean-Pierre; Brione, Willy; Kestemont, Jean-Paul; Stevens, Christophe; Lemair, Xavier; Stephenson, Gregory A.; Marlot, Eric; Forst, Mindy; Houpis, Ioannis N.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4695 - 4705
反应条件
1: 3-(4-hydroxyphenyl)-2-oxo-propionic acid With triethylamine; bis[(1S,2R,3S,5S)-pinan-3-yl]chloroborane in tetrahydrofuran 2: benzyl chloride With potassium carbonate in ethanol 3: With sodium hydroxide in water
参考文献
Aikins, James A.; Haurez, Michael; Rizzo, John R.; Van Hoeck, Jean-Pierre; Brione, Willy; Kestemont, Jean-Paul; Stevens, Christophe; Lemair, Xavier; Stephenson, Gregory A.; Marlot, Eric; Forst, Mindy; Houpis, Ioannis N.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4695 - 4705
反应条件
1: sodium hydride / methanol; diethyl ether / 18 h / 0 - 20 °C 2: hydrogenchloride / water / 0.5 h / 20 °C 3: lithium hydroxide hydrate / water 4: hydrogenchloride; Staphylococcus epidermis D-lactate dehydrogenase; Candida boidinii formate dehydrogenase; ethylenediaminetetraacetic acid; 2-hydroxyethanethiol; ammonium formate; nicotinamide adenine dinucleotide / water / 20 °C / pH 7 / |Enzymatic reaction View Scheme
参考文献
Luettenberg, Sebastian; Ta, Tien Dat; Von Der Heyden, Jan; Scherkenbeck, Juergen
European Journal of Organic Chemistry, 2013 , # 9 p. 1824 - 1830
反应条件
1: lithium hydroxide hydrate / water 2: hydrogenchloride; Staphylococcus epidermis D-lactate dehydrogenase; Candida boidinii formate dehydrogenase; ethylenediaminetetraacetic acid; 2-hydroxyethanethiol; ammonium formate; nicotinamide adenine dinucleotide / water / 20 °C / pH 7 / |Enzymatic reaction View Scheme
参考文献
Luettenberg, Sebastian; Ta, Tien Dat; Von Der Heyden, Jan; Scherkenbeck, Juergen
European Journal of Organic Chemistry, 2013 , # 9 p. 1824 - 1830
反应条件
1: hydrogenchloride / water / 0.5 h / 20 °C 2: lithium hydroxide hydrate / water 3: hydrogenchloride; Staphylococcus epidermis D-lactate dehydrogenase; Candida boidinii formate dehydrogenase; ethylenediaminetetraacetic acid; 2-hydroxyethanethiol; ammonium formate; nicotinamide adenine dinucleotide / water / 20 °C / pH 7 / |Enzymatic reaction View Scheme
参考文献
Luettenberg, Sebastian; Ta, Tien Dat; Von Der Heyden, Jan; Scherkenbeck, Juergen
European Journal of Organic Chemistry, 2013 , # 9 p. 1824 - 1830
反应条件
1: hydrogen; 20 palladium(II) hydroxide on carbon 2: lithium hydroxide hydrate / water; tetrahydrofuran View Scheme
参考文献
Luettenberg, Sebastian; Ta, Tien Dat; Von Der Heyden, Jan; Scherkenbeck, Juergen
European Journal of Organic Chemistry, 2013 , # 9 p. 1824 - 1830
