3-甲氧基-4-硝基苯胺合成路线 （共 19 条）
反应条件
sulfuric acid; urea hydronitrate
T=0 - 4°C; 1 h;
参考文献
Strohmeier, Gernot A.; Fabian, Walter M. F.; Uray, Georg
Helvetica Chimica Acta, 2004 , vol. 87, # 1 p. 215 - 226
反应条件
1: 24 percent / HNO3, Ac2O, AcOH / 1 h
2: 89 percent / aq. HCl / 4 h / Heating
View Scheme
参考文献
Leclerc; Marciniak; Decker; Schwartz
Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2433 - 2438
反应条件
2: 13 g / 85 °C / Hofmann rearrangement
View Scheme
参考文献
Shine, Henry J.; Park, Koon Ha; Brownawell, Marilyn L.; Filippo, Joseph San
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7077 - 7082
反应条件
1: nitric acid / 3 h / -15 - -10 °C
2: potassium carbonate / methanol / 3 h / 20 °C
3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
4: hydrogenchloride / water / Reflux
View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1: potassium carbonate / methanol / 3 h / 20 °C
2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
3: hydrogenchloride / water / Reflux
View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C
2: hydrogenchloride / water / Reflux
View Scheme
参考文献
Arora, Nidhi; Chen, Shaoqing; Hermann, Johannes Cornelius; Kuglstatter, Adreas; Labadie, Sharada Shenvi; Lin, Clara Jeou Jen; Lucas, Matthew C.; Moore, Amy Geraldine; Papp, Eva; Talamas, Francisco Xavier; Wanner, Jutta; Zhai, Yansheng
Patent: US2012/15962 A1, 2012 ;
US 20120015962 A1
反应条件
sodium hydroxide
T=135°C; unter Druck;
参考文献
Hoechster Farbw.
Patent: DE285638 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 12, p. 164
参考文献
du Pont de Nemours and Co.
Patent: US2048790 , 1933 ;
参考文献
Tulp Th.; Hutzinger
Biomedical Mass Spectrometry, 1978 , vol. 5, # 3 p. 224 - 231
