4-碘-2,3,5,6-四氟吡啶合成路线 （共 10 条）
反应条件
1: With n-butyllithium in diethyl ether; hexane
T=-78°C; 1 h;
2: With iodine cloride in diethyl ether; hexane
T=-40°C; 2 h; Further stages.;
参考文献
Abo-Amer, Anwar; Frohn, Hermann-Josef; Steinberg, Christoph; Westphal, Ulrich
Journal of Fluorine Chemistry, 2006 , vol. 127, # 10 SPEC. ISS. p. 1311 - 1323
反应条件
1: neat (no solvent)
2: not given
View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
2: steel wool / neat (no solvent)
3: not given
View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
1.1: diethyl ether / 2 h / -40 - -35 °C / Inert atmosphere
1.2: -40 - 20 °C / Inert atmosphere
2.1: iodine; sodium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Van Nguyen, Ba; Burton, Donald J.
Journal of Fluorine Chemistry, 2012 , vol. 135, p. 144 - 154
反应条件
in further solvent(s)
4-NH2NHC5F4N is slowly added to a suspension of Ag2O in freshly distilled CH3I (0 °C, stirring). Refluxing for 1 h.;
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
in N,N-dimethyl-formamide
bomb tube, H2O-free NaI; at 150 °C (20 h) yield = 84 percent per turnover; at 150 °C (40 h) yield = 58 percent per turnover;;
参考文献
Banks, R. E.; Haszeldine, R. N.; Phillips, E.; Young, I. M.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 2091 - 2095
反应条件
in not given
120 °C (24 h), in presence of AlI3;;
参考文献
Musgrave, W. K. R.
Chemistry and Industry (London, United Kingdom), 1969 , p. 943 - 947
反应条件
1: neat (no solvent, gas phase)
2: neat (no solvent)
3: not given
View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
1: neat (no solvent)
2: not given
View Scheme
参考文献
Gmelin Handbook: F: PerFHalOrg.5, 4, page 115 - 148
反应条件
in sulfuric acid
CO2-inlet at -15 °C (3 h), then 1 h at room temp.;;
参考文献
Banks, R. E.; Haszeldine, R. N.; Phillips, E.; Young, I. M.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 2091 - 2095
