5,5-二甲基-2,2-并噻吩合成路线 （共 31 条）
反应条件
Cl2Ni(1,2-bis(diphenylphosphino)ethane) in diethyl ether 3 h; Heating;
参考文献
Krishnaswamy, N R; Kumar, Ch Siva Sai Ramana
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1992 , vol. 31, # 7 p. 449 - 451
反应条件
1: 2-bromo-5-(5-bromothiophen-2-yl)thiophene With n-butyllithium in tetrahydrofuran; hexane T=0°C; 2: methyl trifluoromethanesulfonate in tetrahydrofuran; hexane T=0°C;
参考文献
Organic Letters, , vol. 10, # 18 p. 3937 - 3940
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride in tetrahydrofuran; toluene T=100°C; 12 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 4 p. 816 - 819
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride in tetrahydrofuran; water; toluene T=100°C; 15 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
1: 2-methyl-5-chlorothiophene With PdCl2(MeCN)2; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in N,N-dimethyl-formamide T=20°C; Sonogashira coupling; 0.5 h; Inert atmosphere; 2: (Tri-iso-propylsilyl)acetylene in N,N-dimethyl-formamide T=100°C; Sonogashira coupling; 18 h; Inert atmosphere;
参考文献
Chemistry - An Asian Journal, , vol. 5, # 5 p. 1202 - 1212
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene T=100°C; 5 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
1: 2-methyl-5-chlorothiophene With PdCl2(MeCN)2; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane T=20°C; Sonogashira coupling; 0.5 h; Inert atmosphere; 2: (Tri-iso-propylsilyl)acetylene in 1,4-dioxane T=100°C; Sonogashira coupling; 17 h; Inert atmosphere;
参考文献
Chemistry - An Asian Journal, , vol. 5, # 5 p. 1202 - 1212
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene T=100°C; 5 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene T=100°C; 2 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tetrabutyl ammonium fluoride; water in tetrahydrofuran; toluene T=100°C; 2 h; Inert atmosphere;
参考文献
Pitteloud, Jean-Philippe; Zhang, Zun-Ting; Liang, Yong; Cabrera, Laura; Wnuk, Stanislaw F.
Journal of Organic Chemistry, 2010 , vol. 75, # 23 p. 8199 - 8212
