(1S,2s)-(+)-反式-1-氨基-2-茚醇合成路线 （共 13 条）
反应条件
ammonia in water T=0°C; 24.5 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2005/99705 A2, 2005 ;
Location in patent: Page/Page column 50 ;
反应条件
hydrogenchloride in methanol; water T=0 - 20°C; Inert atmosphere;
参考文献
Rodriguez-Escrich, Sergi; Sola, Lluis; Jimeno, Ciril; Rodriguez-Escrich, Carles; Pericas, Miquel A.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 14-15 p. 2250 - 2260
参考文献
Hu, Hong; Hollinshead, Sean P.; Hall, Steven E.; Kalter, Kiyomi; Ballas, Lawrence M.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 8 p. 973 - 978
反应条件
N-isopropylcarbamoyl-derivatized cyclofructan-6 column in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Resolution of racemate;
参考文献
Verkuijl, Bastiaan J.V.; De Vries, Johannes G.; Feringa, Ben L.
Chirality, 2011 , vol. 23, # 1 p. 34 - 43
反应条件
lithium aluminium tetrahydride
参考文献
Boyd, Derek R.; Sharma, Narain D.; Bowers, Nigel I.; Goodrich, Peter A.; Groocock, Melanie R.; Blacker, A.John; Clarke, David A.; Howard, Tina; Dalton, Howard
Tetrahedron Asymmetry, 1996 , vol. 7, # 6 p. 1559 - 1562
反应条件
water; hydrazine hydrate T=60°C; 3 h; optical yield given as percent ee;
参考文献
Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Parshad, Rajinder; Taneja, Subhash C.
Tetrahedron Asymmetry, 2011 , vol. 22, # 24 p. 2134 - 2143
反应条件
1: 83 percent / (R,R) Jacobson's catalyst, NaOCl, 4-phenylpyridine-N-oxide 2: 81 percent / aq. NH4OH View Scheme
参考文献
Hu, Hong; Hollinshead, Sean P.; Hall, Steven E.; Kalter, Kiyomi; Ballas, Lawrence M.
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 8 p. 973 - 978
反应条件
1: 1.) MeSO2Cl, 2.) KOH 2: 70 percent / NaN3 3: 60 percent / LiAlH4 View Scheme
参考文献
Boyd, Derek R.; Sharma, Narain D.; Bowers, Nigel I.; Goodrich, Peter A.; Groocock, Melanie R.; Blacker, A.John; Clarke, David A.; Howard, Tina; Dalton, Howard
Tetrahedron Asymmetry, 1996 , vol. 7, # 6 p. 1559 - 1562
参考文献
Lehr; Billich; Charpiot; Ettmayer; Scholz; Rosenwirth; Gstach
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2060 - 2067
反应条件
1: 91 percent / Et3N / dimethylformamide / 1 h / Ambient temperature 2: 92 percent / SOCl2 / CH2Cl2 / 3 h / Ambient temperature 3: 92 percent / 20percent H2SO4 / CH2Cl2 / 10 h / Heating View Scheme
参考文献
Lehr; Billich; Charpiot; Ettmayer; Scholz; Rosenwirth; Gstach
Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 2060 - 2067
