2-氨基-5-硝基苯酰胺合成路线 （共 16 条）
反应条件
1: aq. HCl / 1 h
2: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
3: triethylamine / propan-2-ol / 20 °C
4: 84 percent / aq. NaOH / ethanol / 2 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: aq. HCl / 1 h
2: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
3: triethylamine / propan-2-ol / 20 °C
4: 84 percent / aq. NaOH / ethanol / 2 h / 20 °C
5: 91 percent / aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 0 - 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: aq. HCl / 1 h
2: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
3: triethylamine / propan-2-ol / 20 °C
4: 84 percent / aq. NaOH / ethanol / 2 h / 20 °C
5: 1-hydroxybenzotriazole; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide / dimethylformamide; H2O / 0 - 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: aq. HCl / 1 h
2: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
3: triethylamine / propan-2-ol / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
KNO2; acetic acid
unter Kuehlung;
参考文献
Kratz
Journal fuer Praktische Chemie (Leipzig), 1896 , vol. <2> 53, p. 222
反应条件
1: 89 percent / conc. HCl / 1.5 h / 20 °C
2: SOCl2; DMF / 3 h / Heating
3: 403 mg / Et3N / propan-2-ol / 1 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
