2-氨基-5-溴苯甲酰胺合成路线 （共 10 条）
反应条件
ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in water; N,N-dimethyl-formamide T=20°C; 15 h;
参考文献
TIBOTEC PHARMACEUTICALS; VANDYCK, Koen; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard
Patent: WO2012/13643 A1, 2012 ;
Location in patent: Page/Page column 43 ;
反应条件
acetaldehyde oxime; NiII chloride hexahydrate; water 10 h; Reflux; chemoselective reaction;
参考文献
Ma, Xiaoyun; He, Ying; Wang, Pengcheng; Lu, Ming
Applied Organometallic Chemistry, 2012 , vol. 26, # 7 p. 377 - 382
反应条件
ammonium hydroxide 4 h; Ambient temperature;
参考文献
Mohiuddin, Ghulam; Reddy, Padala Satyanarayana; Ahmed, Khalil; Ratnam, Chengalvala Venkata
Journal of Chemical Research, Miniprint, 1987 , # 7 p. 1839 - 1868
反应条件
ammonia in methanol T=20°C; 336 h; Inert atmosphere;
参考文献
Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W.
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351
反应条件
ammonium hydroxide in tetrahydrofuran; water T=0°C; 2 h;
参考文献
Kaniskan, Nevin; Koekten, Sule; Celik, Ilhami
Arkivoc, 2012 , vol. 2012, # 8 p. 198 - 213
参考文献
Guo, MaoJun; Varady, Laszlo; Fokas, Demosthenes; Baldino, Carmen; Yu, Libing
Tetrahedron Letters, 2006 , vol. 47, # 23 p. 3889 - 3892
反应条件
1: Br2 / CCl4 / 1 h / 0 °C 2: aq. NaOH / methanol View Scheme
参考文献
Archiv der Pharmazie, , vol. 314, # 2 p. 176 - 180
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 33, p. 36
反应条件
1: 12 N HCl / 20 °C 2: SOCl2 / dimethylformamide / Heating View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Matsumoto, Mitsuhiro; Obara, Fumihiro; Nagasaki, Takahiro; Hayashi, Hideya
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 545 - 548
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
